May 1, 1975

Immunological polyfunctionality of proteins and its meaning for the analysis of an allergen-active bacterial substrate

Zhurnal mikrobiologii, epidemiologii, i immunobiologii
A N Maianskiĭ

Abstract

It was shown with the aid of immunosorption of an allergen-active substrate of E. coli 020: K84 (No. 2-rII) that protein substances taking part in the phenomenon of cell hypersensitivity were active in the humoral immunity reactions. The allergenic and immunochemical activity served as functions of the same molecules of bacterial proteins, this substantiating the use of immunochemical analysis for the study of an allergen-active bacterial substrate. By protein denaturing it is possible to obtain immunochemical inert allergen-active preparations capable of detecting the cell hypersensitivity to crude bacterial proteins. The problem of immunological polyfunctionality of proteins is discussed from the aspect of nonhomogeneity of their antigenic determinant groups.

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Mentioned in this Paper

Immunoelectrophoresis
Bacterial Proteins
Variolation
Alkalescens-Dispar Group
Humoral Immunity
Allergens
Plasma Protein Binding Capacity
Allergen (brand of diphenylpyraline)
Cell Migration Inhibition Measurement
Macrophage

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