May 1, 1978

Immunological profile in sarcoidosis patients. The in vitro and in vivo effect of thymic humoral factor

Biomedicine / [publiée Pour L'A.A.I.C.I.G.]
B ShohatN Trainin


A study was made of the lymphocytes obtained from 25 patients suffering from sarcoidosis as proved by the Kveim-Siltzbach test and/or organ biopsy. The number of T lymphocytes was determined by the E rosette technique and functional activity by a local xenogeneic graft-versus-host reaction (GVHR) as well as skin tests with PPD, SK-SD, Candida and Trichophyton. In most cases the absolute number of T cells was low and there was an evident impairment of their functional activity. There was also a clear correlation between the severity of impairment of cell-mediated immunity and the clinical stage and activity of the disease. In vitro incubation of the lymphocytes with thymic humoral factor resulted in recovery of the functional activity of the T lymphocytes of 4 of the 7 patients tested, with the previously negative GVHR becoming positive. One of these patients was treated with thymic humoral factor with a resulting restoration of the cell-mediated immune response although there was no evident clinical improvement.

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Mentioned in this Paper

Trichophyton antigen
Lymphocytes as Percentage of Blood Leukocytes (Lab Test)
Graft Vs Host Reaction
Differential White Blood Cell Count Procedure
Candida (fungus)
Thymus Hormones
Kveim Test

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