PMID: 6984843Jan 1, 1982Paper

Immunological properties of peripheral rat lymphocyte subpopulations reacting selectively with guinea pig complement

Immunological Communications
F Kierszenbaum, H M Gharpure

Abstract

Functional properties of peripheral rat T lymphocytes selectively affected by reaction with guinea pig serum (GPS) complement (C) were studied in this work. Cells sensitive to GPS cytotoxicity represented 2-7% of the nucleated cells in the spleen and 1-4% in lymph nodes. Responses of spleen and lymph node cells to Con A and PHA were markedly reduced following treatment with GPS whereas LPS-induced responses were not altered. GPS treatment also abrogated both the specific response of lymph node cells to a protein antigen and the production of leukocyte migration inhibitory factor by splenic cells. By contrast, GPS treatment significantly increased the reactivity of spleen and lymph node cells to alloantigens and enhanced the in vitro immune responsiveness of splenocytes to sheep erythrocytes. These results highlight the selective reactivity of guinea pig C with discrete subsets of immunoregulatory peripheral rat T lymphocytes.

References

Oct 1, 1976·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·B P GothoskarS H Advani
Sep 1, 1974·European Journal of Immunology·R T ActonA F Williams

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Jan 1, 1983·Immunological Communications·H M Gharpure, F Kierszenbaum

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