Immunological properties of two related fragments from human and equine growth hormones

European Journal of Immunology
M M ZakinA C Paladini

Abstract

The immunological properties of a synthetic human growth hormone fragment comprising the amino acids 73 through 128 and of the homologous natural horse growth fragment formed by amino acids 73 through 123, have been comparatively studied. Antisera obtained in rabbits inoculated with the native human hormone or with the fragments, were used. By hemagglutination experiments both fragments have the same reactivity toward the anti-human growth hormone serum, but complement fixation curves detect the existence of at least two populations of antibodies presumably originated against the sequence 73-128 of human growth hormone. Of these, only one of the corresponding antigenic areas is present in the homologous region of equine growth hormone. The known cross-reactivity detected between both hormones is thus partially explained.

References

Jun 1, 1976·European Journal of Immunology·E PoskusA C Paladini
May 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·C R ReaganA E Wilhelmi
Jan 1, 1976·International Journal of Peptide and Protein Research·M M ZakinA C Paladini
Apr 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·C H Li, L Gráf
Jan 15, 1974·Biochemistry·P Y Chou, G D Fasman
Aug 23, 1972·Nature: New Biology·F ChillemiA Pecile

Citations

Dec 1, 1980·Molecular Immunology·C PeñaA C Paladini
Jan 1, 1985·Pharmacology & Therapeutics·R Aston, J Ivanyi
Oct 28, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Franco M MuggiaStephen B Howell
Dec 1, 1979·European Journal of Immunology·P FerraraA C Paladini
Jan 1, 1983·CRC Critical Reviews in Biochemistry·A C PaladiniE Poskus
Sep 1, 1981·International Journal of Peptide and Protein Research·C PeñaA C Paladini
Feb 1, 1990·International Journal of Peptide and Protein Research·B Mollerach-GobbiC Peña

Related Concepts

Complement Fixation Tests
Hemagglutination Test
Immune Sera
Protein Conformation
Recombinant Growth Hormone

Related Feeds

Antibodies: Complement Activation

The complement system can be activated by antigen-associated antibody. In the classical pathway of complement activation, C1q, C4b, and C3b are all able to bind to the Fc portion of IgG or IgM. Find the latest research on antibodies and complement activation here.