Immunological recovery and antiretroviral therapy in HIV-1 infection

The Lancet Infectious Diseases
Manuel BattegayGilbert R Kaufmann

Abstract

Potent antiretroviral therapy has dramatically improved the prognosis of patients infected with HIV-1. Primary and secondary prophylaxis against Pneumocystis carinii, Mycobacterium avium, cytomegalovirus, and other pathogens can be discontinued safely once CD4 cell counts have increased beyond pathogen-specific thresholds. Approximately one-third of individuals receiving antiretroviral therapy will not reach CD4 cell counts above 500 cells per muL after 5 years despite continuous suppression of plasma HIV-1 RNA. Whether this failure represents a risk factor for the long-term incidence of opportunistic diseases--eg, tuberculosis or malignancies--remains uncertain. We describe the time course of CD4 cell concentrations in patients whose plasma HIV-1 RNA is durably suppressed by antiretroviral therapy, in patients with incomplete suppression of plasma HIV-1 RNA, and during treatment interruptions. In addition, immune reconstitution disease, an inflammatory syndrome associated with immunological recovery occurring days to weeks after the start of antiretroviral therapy, is briefly described.

References

Nov 14, 1997·Proceedings of the National Academy of Sciences of the United States of America·J K WongD D Richman
Aug 8, 1998·The New England Journal of Medicine·S H MichaelsP Kissinger
Nov 30, 1999·JAMA : the Journal of the American Medical Association·S M WhitcupM A Polis
May 15, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Asda VibhagoolAtiporn Ingsathit
May 28, 2003·Archives of Internal Medicine·Catherine FagardUNKNOWN Swiss HIV Cohort Study
Mar 5, 2004·The New England Journal of Medicine·Carolyn F WilliamsJack T Stapleton
Apr 20, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Hans H HirschManuel Battegay
Apr 29, 2004·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·L AaronO Lortholary
Jul 29, 2004·AIDS·Martyn A FrenchShelley F Stone
Feb 17, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Reto NueschKiat Ruxrungtham
Jul 12, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Sarah C SassonDavid A Cooper
Jul 19, 2005·The Journal of Clinical Investigation·Joseph A KovacsH Clifford Lane
Oct 6, 2005·The Journal of Infectious Diseases·Steven G DeeksJeffrey N Martin

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Citations

Sep 24, 2008·Archives of Internal Medicine·Eran BendavidDouglas K Owens
May 15, 2013·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Isabelle Poizot-MartinCatherine Tamalet
Nov 4, 2006·Nature Clinical Practice. Endocrinology & Metabolism·Ann Danoff
Sep 12, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Nina KhannaUNKNOWN Swiss HIV Cohort Study
Feb 6, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Colleen F KelleySteven G Deeks
Oct 22, 2008·AIDS Research and Human Retroviruses·Carolien J P Van Den Bout-Van Den BeukelAndré J A M Van Der Ven
May 23, 2012·AIDS Research and Human Retroviruses·José R BlancoUNKNOWN CoRIS
Oct 1, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Taisheng LiYanling Li
Jan 19, 2011·Current Opinion in HIV and AIDS·Scott G Kitchen, Jerome A Zack
May 7, 2011·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Hemant KulkarniVincent C Marconi
Sep 29, 2012·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Sophia PathaiStephen D Lawn
Feb 5, 2009·Respirology : Official Journal of the Asian Pacific Society of Respirology·Kristina Crothers, Laurence Huang
Oct 6, 2012·HIV Medicine·S T WrightUNKNOWN Australian HIV Observational Database study group
Jan 19, 2008·American Journal of Respiratory and Critical Care Medicine·Stephen D LawnRobin Wood
Jul 25, 2009·American Journal of Respiratory and Critical Care Medicine·Katalin A WilkinsonRobert J Wilkinson
Jan 20, 2011·AIDS Research and Therapy·Alan R LifsonUNKNOWN Infectious Disease Clinical Research Program (IDCRP) HIV Working Group
Dec 12, 2012·Continuum : Lifelong Learning in Neurology·Sarah M Kranick, Avindra Nath
May 10, 2012·Drug, Healthcare and Patient Safety·Omary Mashiku MinziGodeliver A Kagashe
Jun 4, 2010·Drugs·Sarah L PettSean Emery
Oct 25, 2013·Lancet·Steven G DeeksDiane V Havlir

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