Immunological responses and evaluation of the protection in dairy cows vaccinated with staphylococcal surface proteins

Veterinary Immunology and Immunopathology
C MerrillO Kerro Dego

Abstract

Bovine mastitis is a significant cause of economic losses in the dairy industry. Staphylococcus aureus is one of the most common contagious mastitis pathogens, whereas Staphylococcus chromogenes increasingly became a significant cause of subclinical mastitis in dairy cows. Current mastitis control measures are not effective on all mastitis pathogens. There is no effective vaccine to control Staphylococcal mastitis in dairy cows. The objective of this study was to evaluate the immune responses and protection in dairy cows vaccinated with S. aureus surface proteins (SASP) or S. chromogenes surface proteins (SCSP). We divided eighteen Holstein dairy cows randomly into three groups of 6 animals each. We vaccinated group 1 and 2 animals with SASP and SCSP with Emulsigen-D adjuvant, respectively. We injected control (group 3) animals with PBS (pH 7.2) in Emulsigen®-D. We vaccinated animals three times at 28 and 14 days before drying off, and at dry off. Two weeks after the third vaccination, we challenged each animal by dipping all teats in S. aureus culture suspension once daily for 14 consecutive days. We evaluated milk or mammary secretion and serum antibody titers during vaccination and challenge periods. We evaluated milk sample...Continue Reading

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Citations

Jan 13, 2021·Animals : an Open Access Journal From MDPI·Reta D AbdiOudessa Kerro Dego
Apr 1, 2021·Tropical Animal Health and Production·Amr El-Sayed, Mohamed Kamel
May 11, 2021·Veterinary Immunology and Immunopathology·Kezia R FourieHeather L Wilson

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