Immunological responses of the rabbit host to infestation by the brown ear-tick Rhipicephalus appendiculatus (Acarina:Ixodidae)

Experimental & Applied Acarology
B H Fivaz


Rabbits developed resistance to Rhipicephalus appendiculatus instars following repetitive infestations. Rejection was accompanied by elevated IgM and IgG titres. Extracts of salivary gland, mouth-part cement and whole ticks induced a dose-related lymphocyte transformation. Skin-provocation tests with tick extracts elicited an immediate type-I hypersensitivity reaction with a delayed time-course which was influenced by antihistamines. Passive-transfer studies indicated that resistance was partially transferred with serum. A comparative histological study of the attachment sites of larvae on resistant and naive hosts demonstrated the role of eosinophils and macrophages during the initial phase of infestation. Possible rejection mechanisms are discussed in the light of these and other findings.


Jan 1, 1990·Experimental & Applied Acarology·B H Fivaz, A Norval
Apr 1, 1993·Medical and Veterinary Entomology·S Schorderet, M Brossard


Aug 1, 1986·International Journal for Parasitology·A R Walker, J D Fletcher
Dec 31, 1966·Lancet·J F Riley
Sep 1, 1970·The Journal of Experimental Medicine·H F DvorakM J Karnovsky
Jan 15, 1981·Experientia·A V SchlegerD H Kemp

Related Concepts

Attachment Sites, Microbiological
Immediate Hypersensitivity
Immune Sera
Suborder Ixodides
Dose-Response Relationship, Immunologic
Lymphocyte Activation
Eosinophils as Percentage of Blood Leukocytes

Related Feeds

Atopic Dermatitis

Atopic dermatitis is a chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. Discover the latest research on atopic dermatitis here.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.