Immunological responses of the rabbit host to infestation by the brown ear-tick Rhipicephalus appendiculatus (Acarina:Ixodidae)

Experimental & Applied Acarology
B H Fivaz

Abstract

Rabbits developed resistance to Rhipicephalus appendiculatus instars following repetitive infestations. Rejection was accompanied by elevated IgM and IgG titres. Extracts of salivary gland, mouth-part cement and whole ticks induced a dose-related lymphocyte transformation. Skin-provocation tests with tick extracts elicited an immediate type-I hypersensitivity reaction with a delayed time-course which was influenced by antihistamines. Passive-transfer studies indicated that resistance was partially transferred with serum. A comparative histological study of the attachment sites of larvae on resistant and naive hosts demonstrated the role of eosinophils and macrophages during the initial phase of infestation. Possible rejection mechanisms are discussed in the light of these and other findings.

References

Jan 1, 1990·Experimental & Applied Acarology·B H Fivaz, A Norval
Apr 1, 1993·Medical and Veterinary Entomology·S Schorderet, M Brossard

Citations

Aug 1, 1986·International Journal for Parasitology·A R Walker, J D Fletcher
Dec 31, 1966·Lancet·J F Riley
Sep 1, 1970·The Journal of Experimental Medicine·H F DvorakM J Karnovsky
Jan 15, 1981·Experientia·A V SchlegerD H Kemp

Related Concepts

Eosinophil
Attachment Sites, Microbiological
Immediate Hypersensitivity
Immune Sera
Suborder Ixodides
IgG2B
Dose-Response Relationship, Immunologic
Larva
Lymphocyte Activation
Eosinophils as Percentage of Blood Leukocytes

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