Immunological responses to influenza vaccination: lessons for improving vaccine efficacy

Current Opinion in Immunology
Taia T WangJeffrey V Ravetch

Abstract

A critical factor in the maturation of influenza vaccine responses is the nearly inevitable binding of vaccine antigens by exiting anti-influenza IgGs. These antigen-IgG immune complexes direct the response to immunization by modulating cellular processes that determine antibody and T-cell repertoires: maturation of dendritic cells, processing and presentation of antigens to T cells, trafficking of antigens to the germinal center, and selection of B cells for antibody production. By focusing on the recent advances in the study of the immunomodulatory processes mediated by IgG immune complexes upon influenza vaccination, we discuss a pathway that is critical for modulating the breadth and potency of anti-HA antibody responses and has previously led to the development of strategies to improve influenza vaccine efficacy.

Citations

Jan 9, 2020·Immunology and Cell Biology·Hillary A Vanderven, Stephen J Kent
Apr 6, 2019·Frontiers in Immunology·Carolyn M Boudreau, Galit Alter
Jul 3, 2021·Viruses·Kristin B WigginsStacey Schultz-Cherry

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