PMID: 7009436Feb 1, 1981Paper

Immunological sterilization of male dogs by BCG

International Journal of Andrology
R K Naz, G P Talwar

Abstract

The effect of a single intratesticular injection of Freund's complete adjuvant (FCA), incomplete Freund's adjuvant (IFA) and various components has been investigated in dogs. FCA caused severe granulomatous reaction with wide-spread degeneration and vacuolation of the tubules. IFA and Arlacel A induced oligo - but not azoospermia, which was of short duration (6 weeks). Bacillus Calmette Guerin (BCG) suspended in saline given with uniform distribution at doses of 10 units or higher was effective in inducing aspermatogenesis. The sperm count declined to near zero level within 3 to 6 weeks after injection of BCG, and sperm suppression was maintained for 6 to 11 months of the observation period. At moderate doses of 10 to 25 units partial to complete inhibition of spermatogenesis was seen in different tubules with leukocyte infiltration in the interstitium. The basement membrane of the tubules, the peritubular cells as well as the Leydig cells were intact. At high doses (75-110 units) and at sites where bacillary deposits were high even in moderate dose animals, there was massive leukocyte infiltration with nonspecific damage to the tubules. The animals, on low or high dose, retained libido and copulated with bitches in oestrus. Th...Continue Reading

References

Nov 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·G P TalwarR P Das
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Nov 1, 1974·Science·T H Maugh

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Citations

Sep 1, 1985·Journal of in Vitro Fertilization and Embryo Transfer : IVF·R K NazR J Stillman
Apr 1, 1989·Vaccine·G P Talwar, R Raghupathy
Jun 8, 2006·Theriogenology·Michelle Kutzler, Anna Wood
Jul 1, 1986·Journal of Andrology·R K Naz, G P Talwar
Sep 1, 1981·Archives of Andrology·G P Talwar, R K Naz

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