PMID: 6970755Apr 1, 1981Paper

Immunological studies of aging. Decreased production of and response to T cell growth factor by lymphocytes from aged humans

The Journal of Clinical Investigation
S GillisM E Weksler

Abstract

Human lymphocytes from elderly and young donors were cultured with phytohemagglutinin (PHA) or concanavalin A. Cultures from old donors produced less T cell growth factor (TCGF) and incorporated less tritiated thymidine (3H-Tdr) than did similar cultures from young donors in the presence of either mitogen. Furthermore, the response of lymphocytes from elderly donors to TCGF was impaired. Thus, PHA-activated T cells from aged donors showed no increase tritiated thymidine incorporation when incubated with exogenous human TCGF. In contrast, addition of exogenous human TCGF to PHA-activated peripheral blood leukocytes from younger individuals increased tritiated thymidine incorporation by 30-50%. The impaired response to TCGF was associated with decreased binding of TCGF by PHA-activated cells from old donors. TCGF production or responsiveness was not associated with the presence of "suppressor" activity in elderly T cell preparations. These studies suggest a possible molecular mechanism for the impaired proliferative response of elderly human T cells. These data lend support to the hypothesis that defects in the capacity to either produce or respond to TCGF may be a fundamental cause of immune deficiency.

References

Jun 1, 1977·Cellular Immunology·R E CallardL K Waters
Jul 14, 1977·Nature·S Gillis, K A Smith
Aug 1, 1979·European Journal of Immunology·A CoutinhoJ Andersson
Oct 1, 1978·The Journal of Experimental Medicine·S GillisK A Smith
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Jan 1, 1974·The Journal of Clinical Investigation·M E Weksler, T H Hütteroth
May 1, 1980·Molecular Immunology·K A SmithF W Ruscetti

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Citations

Oct 8, 1997·Cancer·W B Ershler, D L Longo
Jan 1, 1994·Annals of Neurology·M E Weksler
Sep 1, 1984·The Japanese Journal of Surgery·T AkiyoshiH Tsuji
Sep 1, 1985·The Japanese Journal of Surgery·T AkiyoshiH Tsuji
Jan 1, 1997·International Journal of Clinical & Laboratory Research·M C HonoratiA Facchini
Feb 1, 1994·Aging : Clinical and Experimental Research·D R JackolaR A Miller
Jun 16, 2010·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Amy S TurmelleGary F McCracken
Oct 1, 1998·Age·E D Bernstein, D M Murasko
Apr 6, 2012·Immunologic Research·Paulina Dominika RymkiewiczAnis Larbi
Nov 30, 1984·Journal of Immunological Methods·C De Vos, W Libert
Jan 1, 1988·Life Sciences·D D LiH T Cheung
Mar 1, 1984·Mechanisms of Ageing and Development·M Bruley-Rosset, I Vergnon
Nov 1, 1985·Mechanisms of Ageing and Development·G W CanonicaH H Fudenberg
Nov 1, 1985·Mechanisms of Ageing and Development·H RabinowichA Klajman
May 31, 1985·Mechanisms of Ageing and Development·S AntonaciL Bonomo
Sep 14, 1987·Mechanisms of Ageing and Development·S BrillA Globerson
Sep 1, 1988·Mechanisms of Ageing and Development·D R Davila, K W Kelley
Aug 1, 1993·Mechanisms of Ageing and Development·J SindermannH Kirchner
Apr 21, 1995·Mechanisms of Ageing and Development·D C NormanT T Yoshikawa
May 12, 1995·Mechanisms of Ageing and Development·N DoninJ Leibovici
Jul 5, 1996·Mechanisms of Ageing and Development·M A PhelouzatJ J Proust
Aug 29, 1996·Mechanisms of Ageing and Development·M A Pahlavani, A Richardson
Jul 31, 1996·Mechanisms of Ageing and Development·D LioC Caruso
Nov 15, 1989·Veterinary Immunology and Immunopathology·K L Knudtson, S J Lamont
Jun 1, 1994·Immunology Letters·J W Albright, J F Albright

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