PMID: 9175026Jan 1, 1997Paper

Immunologically restricted and inhibitory anti-Ro/SSA in monozygotic twins

Lupus
R Hal ScofieldM Reichlin

Abstract

A pair of monozygotic twins with Sjögren's syndrome are described who both have large amounts of anti-Ro/SSA in their sera by ELISA, but no precipitin in double immunodiffusion. Unique among previously encountered specimens, sera from the twins inhibit the formation of Ro/SSA-precipitins in double immunodiffusion by known anti-Ro/SSA positive SLE patients. The twins have near identical, clonally restricted anti-Ro/SSA autoantibodies as evaluated by isoelectric focusing and bind the same 60 kD Ro/SSA peptides. Thus, this pair of monozygotic twins has an identical fine specificity in their immune response to 60 kD Ro/SSA, despite potential differences in their immune response generated by random processes in the formation of immunoglobulin molecules and T cell receptors. These data imply that the anti-Ro/SSA found in these sera binds less than three epitopes such that soluble antigen/antibody complexes are formed instead of an insoluble complex that precipitates.

References

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Apr 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·R H Scofield, J B Harley
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Oct 27, 1997·Clinical and Experimental Immunology·R H ScofieldJ B Harley

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Citations

Aug 27, 1998·Electrophoresis·B T KurienR H Scofield
Jul 14, 2009·Current Opinion in Rheumatology·R Hal Scofield
Nov 14, 2007·Annals of the Rheumatic Diseases·Jeffrey LeeKarl Gaffney
Apr 20, 2007·Medical Hypotheses·Biji T KurienR Hal Scofield
Feb 1, 2012·Journal of Autoimmunity·John A IceKathy L Moser
Nov 6, 2008·Rheumatic Diseases Clinics of North America·Beth L CobbKathy L Moser
May 28, 2014·International Journal of Rheumatic Diseases·Won-Seok Lee, Wan-Hee Yoo
Apr 14, 2016·Joint, Bone, Spine : Revue Du Rhumatisme·Nathalie C Lambert
Nov 5, 2014·Antioxidants & Redox Signaling·Giuseppina BarreraFabrizio Gentile
Mar 26, 2008·Journal of Dental Research·S A MathewsR H Scofield
Feb 17, 2019·Rheumatology·Juliana Imgenberg-KreuzGunnel Nordmark
Nov 2, 2006·British Journal of Nursing : BJN·Ricky Autar
Dec 13, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·R Hal ScofieldBiji T Kurien

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