Sep 28, 2016

Immunology and immunosuppression in kidney transplantation. ABO and HLA incompatible kidney transplantation

Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie
F KleinclaussM-O Timsit

Abstract

To perform a state of the art about immunological features in renal transplantation, immunosuppressive drugs and their mechanisms of action and immunologically high risk transplantations such as ABO and HLA-incompatible transplantation. An exhaustive systematic review of the scientific literature was performed in the Medline database (http://www.ncbi.nlm.nih.gov) and Embase (http://www.embase.com) using different associations of the following keywords (MESH): "allogenic response; allograft; immunosuppression; ABO incompatible transplantation; donor specific antibodies; HLA incompatible; desensitization; kidney transplantation". Publications obtained were selected based on methodology, language, date of publication (last 10 years) and relevance. Prospective and retrospective studies, in English or French, review articles; meta-analysis and guidelines were selected and analyzed. This search found 4717 articles. After reading titles and abstracts, 141 were included in the text, based on their relevance. The considerable step in comprehension and knowledge allogeneic response this last few years allowed a better used of immunosuppression and the discover of news immunosuppressive drugs. In the first part of this article, the alloge...Continue Reading

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Mentioned in this Paper

Meta-Analysis (Publications)
Meta Analysis (Statistical Procedure)
Decreased Immunologic Activity [PE]
Blood Group H Type 1 Antigen
Ncbi Taxonomy
Transplantation Immunology
Immunology
HLA Antigens
Kidney
HDDC3

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