Immunology and ovarian cancers.

Journal of the Chinese Medical Association : JCMA
Wen-Ling Lee, Peng-Hui Wang

Abstract

The current standard therapy of epithelial ovarian cancer (EOC) is the combination of surgery and multiagent chemotherapy with/without adding targeted therapy. After treatment, response rate is high and nearly all patients can achieve complete remission, even though they are advanced diseases; however, the majority of patients will relapse and subsequently die of diseases within several years after initial treatment. When treatment options are limited, there is the urgent need for new novel therapeutic approaches for precise cancer control. The development of chemoresistance and evading of the anticancer immune response may be one of the important causes contributing to the therapeutic failure, and therefore, it represents a paradigm shift in cancer research. An individual's immune response and interaction with EOC cells might be one of the key factors for cancer treatment. There are many interventions, including targeting certain type immunogenic EOC-associated antigens, immune checkpoint blockade, and adoptive cellular therapy, which present a profound opportunity to revolutionize EOC treatment. This review will encompass the interaction between EOC and immune system and highlight recent data regarding the research of immunot...Continue Reading

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Citations

Jun 6, 2020·International Journal of Environmental Research and Public Health·Yueh-Han HsuAnd Chia-Ming Chang
Apr 1, 2020·International Journal of Environmental Research and Public Health·Chen-Yu HuangPeng-Hui Wang
Dec 23, 2020·Journal of the Chinese Medical Association : JCMA·Fa-Kung LeePeng-Hui Wang
Jan 23, 2021·Journal of the Chinese Medical Association : JCMA·Wen-Ling LeePeng-Hui Wang
Jan 23, 2021·Journal of the Chinese Medical Association : JCMA·Wen-Ling LeePeng-Hui Wang
Apr 27, 2021·Journal of the Chinese Medical Association : JCMA·Wen-Ling LeePeng-Hui Wang
Aug 26, 2021·Journal of the Chinese Medical Association : JCMA·Peng-Hui WangFa-Kung Lee

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Clinical Trials Mentioned

NCT01968109
NCT02054806
NCT02452424
NCT02459301
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NCT02657889
NCT02671435
NCT02718911
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