Immunology mini-review: the basics of T(H)17 and interleukin-6 in transplantation

Transplantation Proceedings
Tomoyuki NakagiriMeinoshin Okumura

Abstract

The outcomes of organ transplantation are determined by graft rejection, the mechanisms of which are some of the most important areas of study in the transplantation field. The main cause of rejection is the immunologic response of the recipient toward the transplanted organ. The immunologic responses are regulated by T-cell subsets, especially helper T-cells, which have been characterized as T(H)1 or T(H)2 cells according to their profiles of cytokines production. A unique subset of recently identified lymphocytes, the regulatory T cells (T(reg)s), seem to play a role in tolerance. The recently identified T(H)17 cells are a subset of effector-helper lymphocytes that specifically secrete interleukin (IL) 17. Interestingly, T(H)17 and T(reg) both develop from naïve T cells on stimulation by transforming growth factor β. The difference is only the existence of IL-6, a proinflammatory cytokine. T(H)17 clears pathogens that are not adequately handled by T(H)1 and T(H)2 elements, as well as contributing to autoimmune diseases, such as rheumatoid arthritis, systemic lupus erythematosus, and inflammatory diseases. Autoimmune diseases are caused by reactions to self-antigens. T(H)17 (or IL-17) and IL-6 are also thought to be involved i...Continue Reading

References

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Citations

Mar 8, 2013·Future Medicinal Chemistry·Makio Iwashima, Robert Love
Nov 13, 2013·Orphanet Journal of Rare Diseases·Jonathan PoplerRobin R Deterding
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Oct 13, 2021·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Yi-En YaoTian-Xia Huang

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