Immunology of chronic myeloid leukemia: current concepts and future goals

Expert Review of Clinical Immunology
Vladimír Vonka, Martina Petráčková

Abstract

Although chronic myeloid leukemia is a rare malignancy, it has developed into a model system for the study of a variety of aspects of cancer biology and immunology. The introduction of tyrosine kinase inhibitors has resulted in a significant prolongation of the survival rates of chronic myeloid leukemia patients but has not resulted in a cure. There is a growing conviction that this aim can be achieved through immunotherapy. For this concept to be successful, a considerable increase in the present understanding of chronic myeloid leukemia immunology is required. The authors attempt to review and evaluate the current findings that demonstrate a number of immunological aberrations in patients prior to the start of any therapy and their normalization after achieving remission. They also discuss the recent clinical trials with experimental therapeutic vaccines and then present their own strategy on how to address the problem.

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Citations

Mar 18, 2017·Immunotherapy·Wan-Lun YanShih-Jen Liu
Mar 12, 2019·Expert Review of Hematology·Onyee ChanJavier Pinilla-Ibarz
May 10, 2017·Frontiers in Immunology·Amy Hughes, Agnes S M Yong
Mar 9, 2021·World Journal of Clinical Oncology·Mariana Miranda SampaioFabrício Freire de Melo

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