PMID: 9430169Jan 16, 1998Paper

Immunology of HIV and pregnancy. The effects of each on the other

Obstetrics and Gynecology Clinics of North America
D V LandersB A Coyne

Abstract

Infection with HIV may significantly affect the human immune response. Depletion of CD4 T cells directly or indirectly results in global immune dysfunction, including both cellular and humoral components of the immune system. Ongoing viral replication leads to progressive immune destruction despite apparent clinical latency. The end result, if left untreated, is CD4 T-cell depletion, severe immune compromise, opportunistic infection, and eventual death. Pregnancy has been purported to induce an altered immune state to protect the fetus from immune rejection that may leave the mother with impaired immunity. This theoretical risk has been overemphasized, and, in fact, only limited data suggest that certain infections may have worse presentations and outcomes during pregnancy. The mother maintains immunocompetence throughout gestation and is not overwhelmed with opportunistic infection. Women infected with HIV may experience some decline in CD4 T-cell percentages and possibly in function. It is not clear whether any of the effects will significantly affect long-term outcome. Infection with HIV may predispose pregnant women to a variety of adverse pregnancy outcomes, including preterm labor, prematurity, low-birth-weight infants, p...Continue Reading

References

Jun 1, 1992·AIDS Research and Human Retroviruses·C Mackewicz, J A Levy
Jan 26, 1995·The New England Journal of Medicine·D Baltimore
Jun 1, 1994·Obstetrics and Gynecology·F D JohnstoneJ Whitelaw
Nov 1, 1995·British Journal of Obstetrics and Gynaecology·C ThorneC Peckham
Jun 28, 1996·Science·R A Weiss

❮ Previous
Next ❯

Citations

May 29, 2003·Journal of Clinical Anesthesia·Krzysztof M Kuczkowski
Dec 29, 2000·Health Psychology : Official Journal of the Division of Health Psychology, American Psychological Association·J R IckovicsM I Fernandez
Aug 13, 2013·Infectious Diseases in Obstetrics and Gynecology·Elisabeth SappenfieldAthena P Kourtis
Feb 7, 2002·The Journal of the Association of Nurses in AIDS Care : JANAC·Ellen TedaldiPeter Axelrod
Jan 15, 2004·Obstetrics and Gynecology Clinics of North America·Helen E Cejtin
Nov 15, 2000·Revista latino-americana de enfermagem·M J Vaz, S M de Barros
Oct 28, 2016·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Athena P KourtisUNKNOWN Partners in Prevention HSVHIV Transmission Study and Partners PrEP Study Teams

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.