PMID: 7337147Jan 1, 1980Paper

Immunology of spontaneous abortion and hydatidiform mole

American Journal of Reproductive Immunology : AJRI
S Takeuchi

Abstract

Our study of the sequence of morphological events leading to the formation of hydatidiform mole (HM) led us to this study. Our object in this paper is to present evidence supporting our 1971 hypothesis with results obtained by various immunological methods in our laboratory, and to propose the importance of an immunoregulatory mechanism by blocking antibody (BA). Our hypothesis is that the conceptus, after the early demise of the embryo, may be dropped out in most cases as spontaneous abortion (SpA), and the trophoblast in the remaining cases continues to grow, developing into HM by an "immune selection" mechanism. Our conclusion is that the trophoblast will be damaged by immune cytotoxic mechanism through a decrease of BA in SpA, and continue to grow in HM through continuous production of BA after the demise of the embryo.

References

Aug 1, 1976·British Journal of Obstetrics and Gynaecology·S D LawlerK D Bagshawe
May 1, 1976·American Journal of Obstetrics and Gynecology·J G LauritsenN Grunnet
Jan 1, 1978·Journal of the National Cancer Institute·N WakeM Sasaki
May 1, 1978·American Journal of Obstetrics and Gynecology·T Kajii, A Ferrier
Jun 1, 1976·Clinical Genetics·J G LauritsenF Kissmeyer-Nielsen
Feb 29, 1976·Human Genetics·M R CreasyE D Alberman

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Citations

Jan 1, 1986·Cancer Metastasis Reviews·R S BerkowitzD J Anderson
Jan 1, 1993·Immunologic Research·I A RooneyJ P Atkinson
Dec 1, 1990·American Journal of Reproductive Immunology : AJRI·S Takeuchi
Jan 1, 1992·Transfusion Medicine Reviews·A M Unander
Jan 6, 2007·Clinical Genetics·R Slim, A Mehio
Sep 1, 1989·American Journal of Reproductive Immunology : AJRI·C A LabarrereO H Althabe
Oct 1, 1989·American Journal of Reproductive Immunology : AJRI·S GotoS Takeuchi
Apr 1, 1983·American Journal of Reproductive Immunology : AJRI·J Hanaoka, S Takeuchi
Dec 1, 1983·American Journal of Reproductive Immunology : AJRI·A M Unander, L B Olding
Jul 1, 1984·American Journal of Reproductive Immunology : AJRI·P C HoH K Ma
Sep 1, 1988·Tissue Antigens·H E HansenS O Larsen
Jul 1, 1991·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·I HasegawaS Takeuchi
Apr 1, 2018·American Journal of Reproductive Immunology : AJRI·Hamed HajipourMohammad Nouri
Apr 1, 1986·American Journal of Reproductive Immunology and Microbiology : AJRIM·C A Labarrere, O H Althabe
Jan 1, 1986·American Journal of Reproductive Immunology and Microbiology : AJRIM·C LabarrereD Muscolo
Jan 1, 1986·American Journal of Reproductive Immunology and Microbiology : AJRIM·K TakakuwaS Takeuchi

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