Immunology-related perturbations induced by copper and chitosan in carp (Cyprinus carpio L.)

Archives of Environmental Contamination and Toxicology
C DautremepuitsGuy Vernet

Abstract

Copper is used in treatment mixtures to control fungal diseases in vineyards. Its concentrations are relatively high in some aquatic ecosystems, and the main problem observed in this study was the antioxidant stress induced by this heavy metal. Copper toxicologic effects in aquatic organisms have prompted the demand for alternative use of low-toxicity molecules in culture treatments. Chitosan is a polymer with antifungal property similar to copper and may be an interesting biopesticide. Thus, it is necessary to investigate the potential toxicity of chitosan for aquatic animal health, either alone or in conjunction with copper. In this study, carp were exposed to two sublethal chitosan concentrations (75 and 150 mg/L) or to two sublethal copper concentrations (0.1 and 0.25 mg/L) or to a mixture of chitosan plus copper (75 mg/L and 0.1 mg/L, respectively). The results of the present study show that exposure to copper at environmentally realistic levels or to chitosan at sublethal concentrations may significantly stimulate various aspects of immune functions in carp such as nonspecific cellular immunity, represented by total immunoglobulin level, ceruloplasmin activity, and oxidative activity of phagocytes. This acute-phase inflam...Continue Reading

Citations

Feb 8, 2008·Archives of Pharmacal Research·Kyung Sin BaekSe Young Choung
Aug 1, 2007·Pakistan Journal of Biological Sciences : PJBS·S ZareS Shiri
Jul 6, 2014·Environmental Science and Pollution Research International·S JollyS Betoulle
May 31, 2015·Ecotoxicology and Environmental Safety·Anne Bado-NillesStéphane Betoulle
Sep 27, 2015·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Aliakbar HedayatiSeyed Hossein Hoseinifar
Nov 12, 2021·Journal of Experimental Zoology. Part A, Ecological and Integrative Physiology·Seyyed Morteza HoseiniHien Van Doan

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