PMID: 9192362May 1, 1997Paper

Immunomapping of basement membrane zone macromolecules in canine salt-split skin

The Journal of Veterinary Medical Science
T IwasakiY Sasaki

Abstract

Certain macromolecules of human and canine cutaneous basement membrane zone (BMZ) have shown to have responsibilities for pathogenesis of mechanobullous skin diseases. Salt-split skin by 1 M NaCl have been used for diagnosis of human mechanobullous diseases. However, there have been no studies to characterize canine salt-split skin. Electron microscopy of canine salt-split skin showed the separation within lamina lucida. Indirect immunofluorescence revealed the roof of the cleft was labeled by human patient serum with bullous pemphigoid, whereas laminin, laminin 5, type IV and type VII collagen were labeled at the bottom of the cleft. It is suggested that immunomapping of salt-split skin may be useful for the differential diagnosis of canine mechanobullous diseases.

References

Jul 1, 1992·Journal of the American Academy of Dermatology·W R GammonR A Briggaman
Jan 1, 1990·Annals of the New York Academy of Sciences·R E BurgesonD R Keene
Feb 1, 1988·The Journal of Investigative Dermatology·T YoshiikeR A Briggaman
Mar 1, 1988·The Journal of Clinical Investigation·D T WoodleyR A Briggaman
Aug 1, 1983·The Journal of Investigative Dermatology·D WoodleyE Qwarnstrom
Apr 19, 1984·The New England Journal of Medicine·D T WoodleyW R Gammon
Jan 1, 1983·Annals of the New York Academy of Sciences·D W ScottR M Lewis
Nov 1, 1995·The Journal of Investigative Dermatology·C MatsuiW K Hoeffler
Dec 1, 1995·The British Journal of Dermatology·M NagataT Ishida

❮ Previous
Next ❯

Citations

Jan 17, 2002·Clinical Techniques in Small Animal Practice·T Olivry, H A Jackson
Jul 19, 2016·Veterinary Dermatology·Verena K Affolter
Mar 16, 2000·The Veterinary Record·T OlivryM Chen
Jun 30, 2016·Veterinary Dermatology·Heng L ThamPetra Bizikova
Aug 31, 1999·The Veterinary Record·T OlivryM Chen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bullous Pemphigoid

Bullous pemphigoid is a rare immune system disorder and skin condition that causes large, fluid-filled blisters. Bullous pemphigoid commonly affects older adults and appears in areas such as the lower abdomen, upper thighs or armpits. Discover the latest research on bullous pemphigoid here.