Immunometabolism: new insights and lessons from antigen-directed cellular immune responses.

Seminars in Immunopathology
Renata RamalhoMarkus Maeurer

Abstract

Modulation of immune responses by nutrients is an important area of study in cellular biology and clinical sciences in the context of cancer therapies and anti-pathogen-directed immune responses in health and disease. We review metabolic pathways that influence immune cell function and cellular persistence in chronic infections. We also highlight the role of nutrients in altering the tissue microenvironment with lessons from the tumor microenvironment that shapes the quality and quantity of cellular immune responses. Multiple layers of biological networks, including the nature of nutritional supplements, the genetic background, previous exposures, and gut microbiota status have impact on cellular performance and immune competence against molecularly defined targets. We discuss how immune metabolism determines the differentiation pathway of antigen-specific immune cells and how these insights can be explored to devise better strategies to strengthen anti-pathogen-directed immune responses, while curbing unwanted, non-productive inflammation.

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Citations

Jun 20, 2020·Seminars in Immunopathology·Marcel Tanner
Jan 23, 2021·Clinical Science·Sandro Massao HirabaraRui Curi
Mar 12, 2021·Biochemistry. Biokhimii︠a︡·A Y AndreyevA A Starkov
Sep 3, 2021·Cellular & Molecular Immunology·Xin WangZheng Zhang
Aug 3, 2021·Antimicrobial Agents and Chemotherapy·Bridgette M CummingAdrie J C Steyn

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Methods Mentioned

BETA
glycosylation
oncotherapy
xenograft
Acetylation
histone acetylation

Clinical Trials Mentioned

NCT00481455
NCT00117013
NCT03510390
NCT01206764
NCT03324373
NCT01763931
NCT03533127
NCT03278717
NCT02898077
NCT03172299

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