Immunomodulating dose of levamisole stimulates innate immune response and prevents intestinal damage in porcine rotavirus diarrhea: a restricted-randomized, single-blinded, and placebo-controlled clinical trial.

Tropical Animal Health and Production
Gollahalli Eregowda ChethanMed Ram Verma

Abstract

A restricted-randomized, single-blinded, placebo-controlled clinical trial was conducted to examine whether immunomodulating dose of levamisole (LMS) can stimulate certain antiviral immune markers by measuring the concentrations of interferon-γ (IFN-γ), nitric oxide (NOx), and total immunoglobulin G (IgG); prevents the gut injury; and reduces fecal consistency and dehydration scores in rotavirus type A (RVA)-positive piglet diarrhea. The trial was executed between November 2015 and May 2016 in an institute owned experimental swine production farm. The naturally RVA-exposed diarrheic piglets were used in the study. The piglets born between November 2015 and May 2016, age group of 0 to 2 weeks and confirmed for RVA-positive diarrhea, were randomized to receive supportive treatment (ST) or ST along with levamisole (LMS + ST) at immunomodulating dose. Simultaneously, six piglets were randomly selected from healthy population and kept as placebo control. The primary outcome was reduction of fecal consistency and dehydration scores (≤ 1) over the trial period. The secondary outcome was reduction of concentration of gut injury marker and stimulation of immunomodulatory function. The LMS + ST treatment progressively improved the total ...Continue Reading

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Citations

Jul 28, 2020·Animals : an Open Access Journal From MDPI·César BetancurGuillermo Tellez-Isaias
Aug 28, 2020·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·A N BelovaE M Belova
Aug 14, 2021·Viral Immunology·Hayder M Al-KuraishyGaber El-Saber Batiha

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Methods Mentioned

BETA
electrophoresis
PCR
ELISA

Software Mentioned

SAS

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