Immunomodulating role of IL-10-producing B cells in Leishmania amazonensis infection

Cellular Immunology
Luan Firmino-CruzHerbert Leonel de Matos Guedes

Abstract

This work aims to study the immunomodulation of B lymphocytes during L. amazonensis infection. We demonstrated in this study that follicular B cells from draining lymph nodes of infected wild type BALB/c mice are the major source of IL-10 during infection. We infected BALB/Xid mice that developed smaller lesions in comparison with the control, but the parasite load obtained from the infected tissues was similar in both groups. We observed a reduction in the number of follicular B cells from BALB/Xid mice in relation to WT mice and, consequently, lower levels of IgM, IgG, IgG1, IgG2a and IgG2b in the serum of BALB/Xid when compared with wild type mice. BALB/Xid mice also presented lower levels of IL-10 in the infected footpad, draining lymph nodes and in the spleen when compared with WT infected tissues. We did not detect differences in the number of IL-10 producing CD4+ and CD8+ T cells between WT and BALB/Xid mice; however, a strong reduction of IL-10 producing follicular B cells was noted in BALB/Xid mice. When analyzed together, our data indicate that B cells are related with lesion pathogenesis through the production of antibodies and IL-10.

Citations

Jan 1, 2020·Scientific Reports·Alessandra M da Fonseca-MartinsHerbert L de Matos Guedes
Feb 26, 2019·PLoS Neglected Tropical Diseases·Juliana Elena Silveira PrattiHerbert Leonel de Matos Guedes
Jan 30, 2020·Frontiers in Cellular and Infection Microbiology·Luan Firmino-CruzHerbert Leonel de Matos Guedes
Sep 29, 2020·Frontiers in Microbiology·Flávia de Oliveira CardosoKátia da Silva Calabrese
Jun 14, 2019·Frontiers in Medicine·Júlio Souza Dos-SantosHerbert Leonel de Matos Guedes
Jul 25, 2019·Frontiers in Microbiology·Raphael Francisco Dutra Barbosa da RochaDebora Decote-Ricardo
Apr 27, 2019·Frontiers in Cellular and Infection Microbiology·Izabella Pereira da Silva BezerraHerbert Leonel de Matos Guedes
May 7, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Ehab Kotb ElmahallawyAmira A Saleh

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