PMID: 15377883Sep 21, 2004Paper

Immunomodulation and sepsis: impact of the pathogen

Shock
Pierre Moine, Edward Abraham

Abstract

Infection begins when microorganisms overcome host barriers and multiply within host tissues. To contain the infection, the host mounts an inflammatory response that mobilizes defense systems and kills the invading microorganisms. A focal inflammatory response is usually sufficient to eradicate the organisms. However, when it fails to contain the infection, the organisms, their toxins, and numerous host mediators are released into the bloodstream, producing a systemic inflammatory response and organ failure. Microorganisms have coevolved with their hosts, thereby acquiring means of overcoming host defense mechanisms or even taking advantage of innate host responses. Many pathogens avoid recognition by the host or dampen host immune responses via sophisticated pathogen-host interactions. Some pathogens benefit from the inflammatory response. According to current hypotheses regarding the pathogenesis of sepsis, the host generates both an innate immune response identical for all pathogens and an adaptive pathogen-specific response. Determining whether the innate response benefits the pathogen or the host is essential for understanding host-pathogen interactions. In this review, we discuss how pathogens interfere with innate and ad...Continue Reading

References

Dec 4, 1992·Science·K S Kim, J Le
Sep 1, 1990·Infection and Immunity·M ParmelyW W Zhou
Jun 1, 1966·Bacteriological Reviews·M L Gray, A H Killinger
Mar 1, 1994·American Journal of Respiratory Cell and Molecular Biology·S Q SimpsonD E Bice
Mar 1, 1996·Infection·H M HasselhornF W Tiller
Dec 1, 1995·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·D CundellE I Tuomanen
Nov 1, 1996·The Journal of Infectious Diseases·T van der PollS F Lowry
Dec 1, 1996·Infection and Immunity·L L LaichalkT J Standiford
Feb 1, 1997·American Journal of Respiratory and Critical Care Medicine·T van der PollS F Lowry
Jul 1, 1997·Infection and Immunity·J B Rubins, C Pomeroy
Sep 1, 1997·Pediatric Research·E I Tuomanen
Mar 24, 1998·Immunology Today·M J May, S Ghosh
May 29, 1998·Infection and Immunity·M WilsonB Henderson
Nov 24, 1998·Infection and Immunity·A PolissiD Simon
Nov 24, 1998·Infection and Immunity·G M DenningB E Britigan
Dec 29, 1998·Emerging Infectious Diseases·C Van Delden, B H Iglewski
Feb 27, 1999·Current Opinion in Immunology·E B Kopp, R Medzhitov
May 25, 1999·Infection and Immunity·S KanangatD R Schaberg
Jun 8, 1999·European Journal of Immunology·M Kitamura
Sep 3, 1999·American Journal of Respiratory and Critical Care Medicine·G U MeduriD Schaberg

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Citations

Nov 19, 2010·Current Microbiology·Nabonita Sengupta, Syed Imteyaz Alam
May 9, 2006·Journal of Burn Care & Research : Official Publication of the American Burn Association·Kurt A MelstromRavi Shankar
Oct 6, 2005·Shock·Hugo Tannus Furtado de Mendonça-FilhoHugo Caire Castro-Faria-Neto
Dec 20, 2007·Shock·Tobias HirschLars Steinstraesser
Oct 22, 2005·American Journal of Respiratory and Critical Care Medicine·Jean-Louis Vincent, Edward Abraham
Feb 18, 2012·World Journal for Pediatric & Congenital Heart Surgery·Derek S WheelerJoseph A Carcillo
Nov 7, 2009·Critical Care : the Official Journal of the Critical Care Forum·Jin Won HuhYounsuck Koh
Jan 11, 2011·Journal of Conservative Dentistry : JCD·L Lakshmi Narayanan, C Vaishnavi
Oct 14, 2011·Nursing Research and Practice·Sherri Melrose
Mar 14, 2009·The Surgical Clinics of North America·Stephen F Lowry
Oct 14, 2008·International Journal of Antimicrobial Agents·Oliver Kumpf, Ralf R Schumann
Sep 24, 2014·International Journal of Medical Microbiology : IJMM·Jennifer zur BrueggeSoroush Sharbati
May 20, 2008·Journal of Cellular and Molecular Medicine·Florea Lupu
Apr 25, 2007·International Journal of Medical Microbiology : IJMM·Steven M Opal
Mar 13, 2018·Tuberculosis and Respiratory Diseases·Jin Won HuhYounsuck Koh
May 2, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Elizabeth S FernandesSusan D Brain
Nov 15, 2017·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Emma de JongAndrew J Currie
Apr 29, 2009·Journal of Proteome Research·Sung-Ha ParkKwang-Jun Lee

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