PMID: 8962174Dec 1, 1996Paper

Immunomodulation by HLA class I-derived peptides

Transplantation Proceedings
A M Krensky, C Clayberger

Abstract

Synthetic peptides corresponding to linear sequences of HLA class I molecules have profound immunomodulatory effects in vitro and in vivo. Recent clinical trials confirm their potential as the therapeutics for transplantation and for a variety of immune-mediated diseases. These peptides also inhibit NK responses in vivo in humans. The importance of the carboxy end of the alpha 1 alpha helix in negative signaling to both T cells and NK cells focuses attention on new targets for immunotherapy.

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