PMID: 8594302Jan 1, 1996Paper

Immunomodulation by pycnogenol in retrovirus-infected or ethanol-fed mice

Life Sciences
J E CheshierR R Watson

Abstract

Pycnogenol is a commercial mixture of bioflavonoids that exhibits antioxidative activity. The effects of dietary pycnogenol on immune dysfunction in normal mice as well as those fed ethanol or infected with the LP-BM5 murine retrovirus were determined. The ethanol consumption and retrovirus infection caused abnormalities in the function and/or structure of a broad array of cells involved in humoral and cellular immunity. Pycnogenol enhanced in vitro IL-2 production by mitogen-stimulated splenocytes if its production was suppressed in ethanol-fed or retrovirus-infected mice. Mitogenesis of splenocytes did not show a significant change in mice treated with pycnogenol. It reduced the elevated levels of interleukin-6 produced in vitro by cells from retrovirus infected mice and IL-10 secreted by spleen cells from mice consuming ethanol. Natural killer cell cytotoxicity was increased with pycnogenol treatment.

References

Jan 1, 1992·International Archives of Allergy and Immunology·H Spits, R de Waal Malefyt
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Citations

Jul 25, 2007·Cardiovascular Toxicology·Sherma ZibadiRonald Ross Watson
Oct 23, 1997·Journal of the American Dietetic Association·N Spaulding-Albright
Aug 22, 2018·Neural Regeneration Research·Bridget Martinez, Philip V Peplow
Mar 26, 2013·The Korean Journal of Internal Medicine·Min-Sung LeeAn-Soo Jang

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