PMID: 9170480Jun 1, 1997Paper

Immunomodulation in women with endometriosis receiving GnRH agonist

Obstetrics and Gynecology
C C HsuK E Huang

Abstract

To assess the changes in the subpopulations of lymphocytes and in lymphocyte mitogenic activity in women with endometriosis receiving GnRH-agonist treatment. Twenty-six women with advanced endometriosis from the National Cheng Kung University Medical College were studied. Each received a total of six doses of GnRH agonist at 4-week intervals. Immunologic responses at various times after receiving GnRH-agonist treatment, including numbers of peripheral blood lymphocytes subsets and the lymphocyte proliferative activity, were analyzed using a repeated measures analysis of variance. Twenty-six healthy women who visited our gynecologic clinics for routine Papanicolaou smear examination at the time of the recruitment were enrolled as controls. The responses for each patient receiving GnRH agonist were normalized with respect to those of her matched control at each of the time points. The differences between post- and pretreatment data were estimated using generalized estimating equations. There was no significant difference in the sizes of lymphocyte subsets between patients and controls before treatment. After GnRH-agonist treatment, there was a trend in the rise of natural killer cell numbers early in the treatment period, with P ...Continue Reading

References

Aug 1, 1992·American Journal of Reproductive Immunology : AJRI·P ViganóM Vignali
Dec 1, 1989·American Journal of Obstetrics and Gynecology·J Halme
Sep 1, 1986·The Journal of Endocrinology·B D GreensteinM J Wheeler
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Citations

Jul 31, 2001·Fertility and Sterility·W B Nothnick
Jan 31, 2002·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·R Gazvani, A Templeton
Jul 7, 1999·Journal of Reproductive Immunology·L M Senturk, A Arici
Apr 3, 2002·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Richard S SchofieldJuan M Aranda
May 24, 2003·Trends in Molecular Medicine·Giuseppe MatareseCarlo Alviggi
Jul 15, 2003·Mediators of Inflammation·Krzysztof SzylloAnna Kamer-Bartosinska
Feb 28, 2003·Biology of Reproduction·Vishwa Deep DixitRajagopala Sridaran
Jun 17, 2011·Science Translational Medicine·Gaoping ZhaoShaoping Deng
Sep 26, 2003·American Journal of Reproductive Immunology : AJRI·Murat Berkkanoglu, Aydin Arici
Jun 30, 2010·American Journal of Reproductive Immunology : AJRI·Yutaka OsugaYuji Taketani
Jan 30, 2004·American Journal of Obstetrics and Gynecology·Kenneth H H Wong, James A Simon
Jul 20, 2007·Internal Medicine·Ken SannoIchiro Nakazawa
Sep 8, 2011·Expert Review of Clinical Immunology·Jennifer L HeringtonKevin G Osteen

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