PMID: 9183518Jan 1, 1996Paper

Immunomodulation of peripheral lymphocytes by hormones of the hypothalamus-pituitary-thyroid axis

Advances in Neuroimmunology
T E Kruger

Abstract

The aim of this review is to provide a comprehensive examination of the current literature describing the immunoregulatory effects on the peripheral immune system by the hormones that comprise the hypothalamic-pituitary-thyroid (HPT) axis. This article discusses the effects of the HPT axis hormones on the peripheral lymphoid tissues and the immune responses mediated by the cells that comprise these lymphoid tissues. Neuroendocrine dysfunction in the HPT axis, either naturally or experimentally induced, and the resulting immune dysfunction are also discussed. Emphasis in this article is placed on the most recent study findings and those that provide a unique or novel way of evaluating HPT hormone effects on the immune system. Our knowledge of the immunoregulatory effects of the hormones that comprise the HPT axis has grown tremendously in the last 10 years. As can be seen in this review, the immunoregulatory effects of the HPT axis hormones are quite diverse and influence most, if not all, aspects of immune system physiology. The continued exploration of the bidirectional circuitry between the immune and neuroendocrine systems may allow for development of appropriate prophylactic procedures that prevent dysfunction in both systems.

References

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Citations

Mar 20, 2010·Clinical Reviews in Allergy & Immunology·Emiliana Konova
Oct 24, 1998·Domestic Animal Endocrinology·S L Davis
Jul 13, 2011·Thyroid : Official Journal of the American Thyroid Association·Paolo De VitoPaul J Davis
Dec 19, 2003·Arthritis Research & Therapy·Farideh EskandariEsther M Sternberg
Jan 17, 2012·Clinical Journal of the American Society of Nephrology : CJASN·Christiaan L MeuweseJuan J Carrero
Feb 16, 2005·Neuroscience Research·Yu-Ping PengJian-Jun Wang
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Dec 2, 2014·PloS One·Hee-Yeon JungUNKNOWN Clinical Research Center for End Stage Renal Disease (CRC for ESRD) Investigators
Feb 3, 2005·Molecular Psychiatry·A Marques-DeakE Sternberg
Sep 1, 2006·Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology·Volkhard SeitzIoannis Anagnostopoulos
Nov 14, 2014·Medical and Veterinary Entomology·N Jaramillo-OI Fonseca-González
Sep 26, 2003·Psychosomatic Medicine·Tanja LangeJan Born
Mar 4, 2006·Experimental Biology and Medicine·John R Klein
Nov 30, 2019·Bulletin of Experimental Biology and Medicine·S N AbdreshovU B Nauryzbai

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