Immunomodulation of peritoneal macrophages by granulocyte-macrophage colony-stimulating factor in humans

Kidney International
Rafael SelgasA Corbí

Abstract

Colony-stimulating factors are growth factors which induce differentiation of the hematopoietic stem cells. Granulocyte-macrophage colony-stimulating factor (GM-CSF) stimulates proliferation and improves functions of neutrophils and monocyte/macrophages. A macrophage submesothelial stratum has been suggested to constitute the first line of peritoneal defense. We have tested whether intraperitoneally administered GM-CSF could increase the number and activation of peritoneal macrophages in peritoneal dialysis patients. Eight stable patients injected 17 micrograms of GM-CSF in each of their four daily CAPD bags over three days. The clinical status, the peritoneal effluent and peripheral blood cell count, membrane receptor expression, phagocytosis activity and cytokine levels were monitored at days 0, 1, 3, 10 and 28. GM-CSF administration caused a large increase in peritoneal macrophage number (89-fold mean increase after 72 hr), returning to baseline seven days after withdrawal. GM-CSF triggered an increase in the expression of CD11b/CD18 (CR3) and its counterreceptor CD54, indicating the cellular progression into a more activated state. Both the number of phagocytic cells (55 +/- 15% to 83 +/- 10%, P < 0.05) and the phagocytic i...Continue Reading

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Citations

Nov 23, 2013·Medical Oncology·Alejandro Francisco-CruzRogelio Hernandez-Pando
Dec 20, 2015·Medicine·Brittany MathiasLyle L Moldawer
May 6, 2016·Peritoneal Dialysis International : Journal of the International Society for Peritoneal Dialysis·Alena ParikovaRaymond T Krediet
Jul 7, 2018·Frontiers in Immunology·Benjamin G Chousterman, Marine Arnaud
Nov 5, 2002·Critical Reviews in Oncology/hematology·A H KlimpT Daemen

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