Immunomodulation of Tumor Vessels: It Takes Two to Tango

Trends in Immunology
Anna Johansson-PercivalRuth Ganss

Abstract

The density of intratumoral CD8+ T cells predicts patient survival and responsiveness to immunotherapy. Effector T cell infiltration in turn is controlled by the tumor vasculature which co-evolves together with an immune-suppressive environment. At the T cell-vascular interface, endothelial cells actively suppress T cell trafficking and function. Conversely, forced activation, normalization, and differentiation of tumor vessels into high endothelial venule entrance portals for lymphocytes can facilitate T cell extravasation. Emerging evidence demonstrates that this process is not exclusively controlled by the endothelium. Indeed, tumor vasculature and CD4+ and/or CD8+ T cells may regulate each other: increasing local effector T cell numbers or re-invigorating pre-existing T cells via immune checkpoint blockade can directly affect the vasculature. A deeper understanding of the orchestration and duration of this reciprocal relationship may help shape the design of future immunotherapies.

Citations

Jun 6, 2020·Frontiers in Immunology·Joseph G SkeateW Martin Kast
May 20, 2020·Journal of Experimental & Clinical Cancer Research : CR·Filippo GalliAlberto Signore
Oct 12, 2019·Cancers·Nako MaishiKyoko Hida
Mar 5, 2019·Frontiers in Immunology·Hari MenonJames W Welsh
Jul 28, 2020·Nature Reviews. Clinical Oncology·Rik DerynckRosemary J Akhurst
Dec 22, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Amanda L WoosterDevin B Lowe
Sep 12, 2020·Molecular Therapy Oncolytics·Mayuresh M ManeRonald G Blasberg
Dec 12, 2020·Acta Pharmaceutica Sinica. B·Yang ZhaoJia Li
Apr 9, 2021·British Journal of Cancer·Anette L Magnussen, Ian G Mills
May 27, 2021·Proceedings of the National Academy of Sciences of the United States of America·Naidong ZhangYuhui Huang
Jun 15, 2021·Frontiers in Immunology·Anna Johansson-Percival, Ruth Ganss

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