Immunomodulative effects of Chinese herbs in mice treated with anti-tumor agent cyclophosphamide

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
R JinS Kurashige

Abstract

Extracts of Chinese herbs were administered with antitumor agent, cyclophosphamide (CY), and their effects on macrophages and lymphocytes were studied. Number of peritoneal macrophages significantly decreased and their chemotactic activity was suppressed by treatment with CY. Blastogenic responsiveness to Concanavalin A and NK cell activity of spleen lymphocytes were suppressed significantly in CY-treated mice. Extracts of Lithospermi radix, Astragali radix and Glycyrrhizae radix showed protective effects on immunosuppressive mice. The number of macrophages, chemotactic activity of macrophages and blastogenic response of lymphocytes were recovered to the same or more than that of normal levels. An extract of Ginseng radix showed protective effects on the number and functions of macrophages by treatment with CY but did not show any effects on the lymphocytic blastogenesis. On the contrary it showed a strong inhibitory effect on the NK cell activity. These results suggest that Chinese herbs could modulate cellular immune response, especially in the activation of macrophages and splenic lymphocytes.

Citations

Apr 2, 2005·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Toshiaki Makino
Jun 29, 2017·Journal of Cellular Biochemistry·You Hee ChoiHye Gwang Jeong
Aug 28, 2003·Integrative Cancer Therapies·Yuan S ChangKeith I Block
Sep 10, 2010·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Young Ock KimSung-Vin Yim
Feb 1, 1996·Immunopharmacology and Immunotoxicology·R Jin, S Kurashige
Dec 12, 2003·Integrative Cancer Therapies·Geoffrey A Cordell
Dec 9, 2015·Chinese Journal of Integrative Medicine·Yeehong JungSookyung Lee

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