Immunomodulatory action of Copaifera spp oleoresins on cytokine production by human monocytes

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Karina Basso SantiagoJosé Maurício Sforcin

Abstract

Copaifera spp oleoresins have been used in folk medicine for centuries; nevertheless, its immunomodulatory action has not been investigated. Thus, the goal of this study was to characterize different oleoresins and to verify their action on human monocytes regarding pro- and anti-inflammatory cytokine production (TNF-α and IL-10, respectively). The chemical composition of Brazilian Copaifera reticulata, Copaifera duckey and Copaifera multijuga oleoresins was analyzed by HPLC-MS. Cell viability was assessed by MTT method after incubation of cells with Copaifera spp. Noncytotoxic concentrations of oleoresins were incubated with human monocytes from healthy donors, and cytokine production was determined by ELISA. HPLC-MS analysis for terpenes allowed the identification of six diterpene acids and one sesquiterpene acid. Oleoresins exerted no cytotoxic effects on human monocytes. All oleoresins had a similar profile: LPS-induced TNF-α production was maintained by oleoresins, while a significant inhibitory action on IL-10 production was seen. Copaifera oleoresins seemed to exert an activator profile on human monocytes without affecting cell viability. Such effect may be due to the presence of either diterpene or sesquiterpene acids; ...Continue Reading

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Citations

Apr 28, 2016·Anaerobe·Danae Kala Rodríguez BardajíCarlos Henrique G Martins
Feb 15, 2017·Evidence-based Complementary and Alternative Medicine : ECAM·Kelly Cristina Oliveira de AlbuquerqueMaria Fâni Dolabela
Apr 13, 2018·Pharmaceutical Biology·Victor Pena RibeiroJairo Kenupp Bastos
Sep 20, 2018·Foodborne Pathogens and Disease·Yadira Arnet FernándezCarlos Henrique Gomes Martins
Jul 28, 2016·Chemistry & Biodiversity·Carly H G BorgesSérgio R Ambrósio
May 28, 2020·Biomolecules·Noelia M Rodriguez-MartinMaria C Millan-Linares
Feb 9, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Jaqueline Lopes DamascenoCarlos Henrique Gomes Martins
Jun 20, 2020·Drug Delivery and Translational Research·Diego R C PascoalSilvio A B Vieira de Melo
Aug 18, 2020·Future Science OA·Jéssica Aparecida AlvesCarlos Henrique Gomes Martins
Jan 29, 2021·Journal of Ethnopharmacology·Guilherme Venâncio SímaroJairo Kenupp Bastos
Nov 6, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Caroline ArrudaJairo Kenupp Bastos

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