PMID: 8588342Nov 1, 1995Paper

Immunomodulatory activity of blood serum from chromium-supplemented periparturient dairy cows

Veterinary Immunology and Immunopathology
J L BurtonD N Mowat

Abstract

Our previous research showed enhanced immune responses, including mitogen-induced blastogenesis of peripheral blood mononuclear cells from feedlot calves and periparturient dairy cows supplemented with dietary chromium (Cr). The objective of the present study were to test whether blood sera from Cr-supplemented periparturient cows contained immunomodulatory activity for mitogen-stimulated peripheral blood mononuclear cells and, if so, to determine if this activity was explicable by differences in blood profiles of some glucose-regulating hormones (insulin, cortisol, growth hormone, insulin-like growth factor I, and tumor necrosis factor-alpha) between Cr-supplemented and unsupplemented (control) animals. Blood sera from ten unsupplemented cows and nine Cr-supplemented cows (0.5 ppm day-1) were collected weekly from 2 weeks before to 6 weeks after parturition, and were used to supplement (1, 10, and 20% vol/vol) culture medium supporting concanavalin A (Con A) stimulated mononuclear cells enriched from blood of four nulliparous donor cows. Hormone concentrations were determined using radioimmunoassays. Con A-induced blastogenesis was enhanced when 1, 10, and 20% sera from Cr-supplemented cows was added to the mononuclear cell cu...Continue Reading

References

Jan 1, 1992·Biological Trace Element Research·W Mertz
Jun 1, 1992·Journal of Inorganic Biochemistry·G W Evans, T D Bowman
Feb 1, 1992·Journal of Animal Science·X Chang, D N Mowat
Jan 1, 1991·European Journal of Applied Physiology and Occupational Physiology·R A AndersonJ W Thorp
Oct 1, 1991·The Journal of Nutrition·B J NonneckeS L Nissen
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May 1, 1993·The British Veterinary Journal·H Murata, T Miyamoto
Apr 1, 1993·The Journal of Nutrition·W Mertz
Aug 1, 1984·Biological Trace Element Research·J S BorelR A Anderson

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Citations

Jan 11, 2000·The Proceedings of the Nutrition Society·J W Spears
Oct 11, 2003·Journal of Veterinary Medicine. B, Infectious Diseases and Veterinary Public Health·M FaldynaJ Krejci
Mar 8, 2008·The Veterinary Journal·Jerry W Spears, William P Weiss
Dec 9, 2008·Veterinary Immunology and Immunopathology·B A MallardP M Coussens

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