Immunomodulatory activity of diethylcarbamazine on humoral, cellular cytokine response and respiratory burst in BALB/c mice

Immunopharmacology and Immunotoxicology
C E Medina-De la GarzaMario C Salinas-Carmona

Abstract

Diethylcarbamazine (DEC) is an anthelmintic piperazine derivative drug with putative immunomodulating properties, including increased platelet and granulocyte adhesion to parasites and enhanced production of cytokines. To further analyse these properties in a well-established animal model, we evaluated the effect of DEC on antibody, cellular cytokine response and respiratory burst in BALB/c mice. Animals were challenged with a thymus-dependent (tetanus toxoid, (TT)) and with a thymus-independent (lipopolysaccharide, (LPS)) antigen and treated with DEC for seven days with two different doses (50 mg/day and 500 mg/day). Serum was assessed for antibody production at 0, 4, 7, 14, 21 and 28 days after stimulation and at 0, 24 and 48 h for IL-2, IFN-γ, IL-10 and IL-12 release. Respiratory burst of neutrophils and monocytes from peripheral blood was measured by flow cytometry. We found low-dose treatment with DEC enhanced cytokine production vs. TT and antibody production vs. LPS, whereas a higher dose enhanced significantly the respiratory burst of both polymorphonuclear leukocytes and monocytes, with a significant higher effect on the former. Our results suggest a stimulating, dose-dependent immunomodulatory effect of DEC with a hig...Continue Reading

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Citations

Apr 15, 2014·European Journal of Pharmacology·Christina Alves Peixoto, Bruna Santos Silva
Aug 26, 2014·International Immunopharmacology·M García-HernándezC E Medina-De la Garza
Mar 19, 2016·Environmental Science and Pollution Research International·Ines DhouibMohamed Montassar Lasram
Jan 13, 2015·International Immunopharmacology·Jeya Prita Parasurama JawaharlalKaliraj Perumal
May 17, 2019·Indian Journal of Clinical Biochemistry : IJCB·Priyanka BhojMandakini Patil
Mar 20, 2020·Journal of Diabetes Research·Juan C Segoviano-RamirezJesús Ancer-Rodriguez
May 20, 2020·Medical Hypotheses·Anuruddha Abeygunasekera, Saroj Jayasinghe

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Anthelmintics (ASM)

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.

Anthelmintics

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.