Abstract
Diethylcarbamazine (DEC) is an anthelmintic piperazine derivative drug with putative immunomodulating properties, including increased platelet and granulocyte adhesion to parasites and enhanced production of cytokines. To further analyse these properties in a well-established animal model, we evaluated the effect of DEC on antibody, cellular cytokine response and respiratory burst in BALB/c mice. Animals were challenged with a thymus-dependent (tetanus toxoid, (TT)) and with a thymus-independent (lipopolysaccharide, (LPS)) antigen and treated with DEC for seven days with two different doses (50 mg/day and 500 mg/day). Serum was assessed for antibody production at 0, 4, 7, 14, 21 and 28 days after stimulation and at 0, 24 and 48 h for IL-2, IFN-γ, IL-10 and IL-12 release. Respiratory burst of neutrophils and monocytes from peripheral blood was measured by flow cytometry. We found low-dose treatment with DEC enhanced cytokine production vs. TT and antibody production vs. LPS, whereas a higher dose enhanced significantly the respiratory burst of both polymorphonuclear leukocytes and monocytes, with a significant higher effect on the former. Our results suggest a stimulating, dose-dependent immunomodulatory effect of DEC with a hig...Continue Reading
References
Jan 1, 1977·Transactions of the Royal Society of Tropical Medicine and Hygiene·G H RéeB C Weatherley
Jan 1, 1992·Parasitology·R M Maizels, D A Denham
Mar 1, 1991·Agents and Actions·C PascualC Romay
Nov 1, 1991·Molecular and Biochemical Parasitology·N Kanesa-thasanJ W Kazura
Sep 1, 1990·Transactions of the Royal Society of Tropical Medicine and Hygiene·C E Medina-De la GarzaJ M Jarrett
Aug 7, 1990·Journal of Immunological Methods·A EmmendörfferJ Roesler
Dec 1, 1987·Vaccine·L W Kitchen
Feb 5, 1987·Nature·J Y CesbronM Joseph
Sep 1, 1983·Antimicrobial Agents and Chemotherapy·C H KingP J Spagnuolo
Nov 1, 1993·Journal of Clinical Microbiology·M C Salinas-CarmonaS M Casillas
Oct 1, 1996·Parasitology·E J Gutiérrez-PeñaD W Büttner
Sep 17, 1998·The Journal of Antimicrobial Chemotherapy·L W KitchenS P Day
Dec 22, 1999·Infection and Immunity·R GopinathT B Nutman
Feb 28, 2002·Journal of Clinical Pharmacology·Sambamoorthy BollaBhaskara R Jasti
Mar 10, 2004·Parasitology Research·C A PeixotoM S Florêncio
Jun 4, 2005·Filaria Journal·Helen F McGarryMark J Taylor
May 24, 2008·Parasitology Research·C A PeixotoC F J Ayres
Sep 1, 1992·International Journal of Antimicrobial Agents·L W KitchenF J Mather
Feb 5, 2009·Expert Opinion on Pharmacotherapy·Erwin van den Enden
Citations
Apr 15, 2014·European Journal of Pharmacology·Christina Alves Peixoto, Bruna Santos Silva
Aug 26, 2014·International Immunopharmacology·M García-HernándezC E Medina-De la Garza
Oct 4, 2015·International Immunopharmacology·Mahmoud Abdel-Latif
Mar 19, 2016·Environmental Science and Pollution Research International·Ines DhouibMohamed Montassar Lasram
Jan 13, 2015·International Immunopharmacology·Jeya Prita Parasurama JawaharlalKaliraj Perumal
May 17, 2019·Indian Journal of Clinical Biochemistry : IJCB·Priyanka BhojMandakini Patil
Mar 20, 2020·Journal of Diabetes Research·Juan C Segoviano-RamirezJesús Ancer-Rodriguez
May 20, 2020·Medical Hypotheses·Anuruddha Abeygunasekera, Saroj Jayasinghe