Immunomodulatory activity of pidotimod administered with standard antibiotic therapy in children hospitalized for community-acquired pneumonia

Journal of Translational Medicine
Susanna EspositoM Clerici

Abstract

Several attempts to improve immune function in young children have been made and encouraging results have been collected with pidotimod (PDT), a synthetic dipeptide molecule that seems to have immunomodulatory activity on both innate and adaptive responses. Until now, the effects of PDT on the immune system have only been studied in vivo after long-term administration to evaluate whether its immunomodulatory activity might prevent the development of infections. This study was planned to evaluate the immunomodulatory activity of PDT administered together with standard antibiotic therapy in children hospitalized for community-acquired pneumonia (CAP). A total of 20 children hospitalized for community-acquired pneumonia (CAP) were randomized at a 1:1 ratio to receive either standard antibiotics plus pidotimod (PDT) or standard antibiotics alone to evaluate the immunomodulatory activity of PDT. Blood samples for the evaluation of immunological parameters were drawn at the time of recruitment (T0) (i.e., before therapy administration), at T3 and T5 (i.e., 3 and 5 days after the initiation of therapy) as well as at T21 (i.e., 7 days after the therapy ended). Following pneumococcal polysaccharide stimulation, the percentage of dendrit...Continue Reading

References

Jan 1, 1992·Immunopharmacology and Immunotoxicology·G MiglioratiC Riccardi
Sep 1, 1992·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·A AuteriG Bova
Jul 1, 1991·Pediatric Hematology and Oncology·G R BurgioA G Ugazio
Dec 27, 2005·Clinical Immunology : the Official Journal of the Clinical Immunology Society·László Maródi
Apr 26, 2007·Nature Reviews. Immunology·Ofer Levy
Feb 2, 2010·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Eduardo Guaní-GuerraLuis M Terán
Feb 13, 2010·Annual Review of Physiology·Scott E EvansBurton F Dickey
Sep 2, 2010·Clinical and Experimental Dermatology·G CiprandiD Fuchs
Dec 24, 2010·Virulence·Jochen Wiesner, Andreas Vilcinskas
Jan 15, 2011·Clinical Microbiology Reviews·Marjolaine VareilleNicolas Regamey
Jan 15, 2011·Clinical & Developmental Immunology·Patricia EwingAllan W Cripps
Aug 27, 2011·European Journal of Pediatrics·Shalom Ben ShimolDavid Greenberg
Oct 11, 2013·BMC Pulmonary Medicine·Francesca PatriaSusanna Esposito
Nov 28, 2013·Paediatric Respiratory Reviews·Wojciech FeleszkoBartłomiej Mateusz Zalewski
Apr 20, 2014·PloS One·Lucja A LabudaAyola A Adegnika
Aug 31, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Gillian TomlinsonJeremy Brown
Oct 4, 2014·International Journal of Immunopathology and Pharmacology·L S Namazova-BaranovaF Scarci
May 2, 2015·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Chiara MameliUNKNOWN AX-Working Group
Feb 16, 2016·International Journal of Obesity : Journal of the International Association for the Study of Obesity·V RainoneD Trabattoni

❮ Previous
Next ❯

Citations

Oct 12, 2019·Expert Review of Anti-infective Therapy·Ning ZhaoXiuyun Liu
Nov 9, 2019·Multidisciplinary Respiratory Medicine·Francesca PuggioniEnrico Heffler
Jul 9, 2020·Italian Journal of Pediatrics·Giulia BrindisiMarzia Duse
Aug 30, 2019·Lung India : Official Organ of Indian Chest Society·Ashok MahashurRishi Jain
Jan 13, 2021·Current HIV Research·Claudio UcciferriJacopo Vecchiet

❮ Previous
Next ❯

Methods Mentioned

BETA
density gradient centrifugation
flow cytometry
PCR

Software Mentioned

SABiosciences
SAS
Intercorp

Related Concepts

Related Feeds

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Bacterial Pneumonia (ASM)

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.

Bacterial Pneumonia

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.