Immunomodulatory effect of Hypoderma lineatum antigens: in vitro effect on bovine lymphocyte proliferation and cytokine production

Parasite Immunology
R PanaderoP Díez-Baños

Abstract

This study examines the immunomodulatory effect of a crude larval extract (CLE), obtained from first stage larvae (L1) of H. lineatum, and the purified fractions hypodermin A (HyA), HyB and HyC. Proliferative responses of peripheral blood mononuclear cells (PBMC) from uninfested and previously infested cattle and the production of the cytokines IL-10, IL-4 and IFN-gamma, in response to concanavalin A (Con A), were determined. The stimulation index of peripheral blood mononuclear cells from uninfested cattle was significantly lower than that from infested animals with the different antigens assayed. The HyA was the antigen that most inhibited the proliferative response, followed by the HyB, the HyC and the CLE. This hypodermin provoked an increase of IFN-gamma and a suppression of IL-10 production that would support a Th1-like cytokine response. The HyB reduced the production of IL-10 stimulated by the Con A in cultures from infested animals. The HyC did not modulate the production of cytokines. Finally, the CLE induced a marked suppression in the production of the different cytokines in cultures from naïve and previously sensitized animals. Our results indicate that Hypoderma larval secretions are comprised of different compone...Continue Reading

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Citations

Jul 8, 2010·Tropical Animal Health and Production·Murtaz-ul HassanManzoor Hussain
Oct 11, 2013·The Journal of Veterinary Medical Science·Wei LiNariaki Nonaka
Jul 22, 2014·Parasite Immunology·R M SandemanD D Colwell
Jan 15, 2014·Parasitology International·Ren-Jin ChenXiao-Rong Zhu
Nov 27, 2014·Cell Biochemistry and Biophysics·An-Kang HuZong-Ping Liu
Nov 9, 2017·Journal of Parasitic Diseases : Official Organ of the Indian Society for Parasitology·Hoda S MohamedMai A Mohamed
Mar 30, 2018·Frontiers in Cellular and Infection Microbiology·Christian StutzerChristine Maritz-Olivier

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