Immunomodulatory effect of mesenchymal stem cells on the immune response of macrophages stimulated by Aspergillus fumigatus conidia

Medical Mycology
Sung-Yeon ChoJung-Hyun Choi

Abstract

Mesenchymal stem cells (MSCs) are known to exert potent immunosuppression and anti-inflammatory effects. There is growing interest in their use for immunotherapy for controlling inflammation as well as acute organ injury. However, there are few reports regarding MSC's immunomodulatory effects in the settings of fungal infection. In this study, we attempted to examine the immunomodulatory effects of MSCs in response to Aspergillus fumigatus. We measured the cytokine response of murine MSCs on the immune response of murine macrophages (J774A.1 cells) evoked by A. fumigatus conidia. In addition, we evaluated the effect of granulocyte-macrophage colony-stimulating factor (GM-CSF) on the MSC-related cytokine response and fungal growth. As a results, after conidia stimulation, tumor necrosis factor (TNF)-α was down-regulated and interleukin (IL)-10 was up-regulated in MSC-treated J774A.1 cells when compared to J774A.1 cells alone. In addition, fungal growth was reduced in MSC-treated J774A.1 cells when compared to J774A.1 cells, which recovered by GM-CSF. However, the effect of MSCs on the cytokine response was not reversed by GM-CSF. NF-κB translocation decreased in MSC-treated J774A.1 cells compared to J774A.1 cells alone. In concl...Continue Reading

References

Sep 16, 2000·Experimental Hematology·R J Deans, A B Moseley
Apr 23, 2005·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Katarina Le Blanc, Olle Ringdén
May 27, 2005·British Journal of Haematology·Shmuel Shoham, Stuart M Levitz
Aug 1, 2007·Blood·Alma J Nauta, Willem E Fibbe
May 13, 2008·Lancet·Katarina Le BlancUNKNOWN Developmental Committee of the European Group for Blood and Marrow Transplantation
Jan 1, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·D NeofytosK Marr
Jan 28, 2009·Nature Reviews. Immunology·Antonio UccelliVito Pistoia
Jul 29, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Natalya V SerbinaEric G Pamer
Oct 14, 2009·Clinical Microbiology Reviews·Stacy J Park, Borna Mehrad
Nov 10, 2009·Journal of Leukocyte Biology·Lieke C J van den BerkRuurd Torensma
Mar 12, 2010·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Dimitrios P KontoyiannisPeter G Pappas
Jun 19, 2010·American Journal of Respiratory and Critical Care Medicine·Shirley H J MeiDuncan J Stewart
Aug 19, 2010·Cellular Microbiology·Allison McCormickFrank Ebel
May 17, 2011·BMC Medicine·Alan TrounsonDon Gibbons
Jun 15, 2011·Current Opinion in Infectious Diseases·Robert A CramerTobias M Hohl
Aug 30, 2011·Trends in Microbiology·Lisa Rizzetto, Duccio Cavalieri
Oct 20, 2011·Molecular Therapy : the Journal of the American Society of Gene Therapy·Darwin J Prockop, Joo Youn Oh
Jan 10, 2012·The Journal of Surgical Research·Todd J WannemuehlerDaniel R Meldrum
Jan 10, 2012·Trends in Immunology·Yufang ShiGuangwen Ren
Mar 20, 2012·American Journal of Physiology. Lung Cellular and Molecular Physiology·Anna KrasnodembskayaMichael A Matthay
Apr 26, 2012·Nature Reviews. Immunology·Katarina Le Blanc, Dimitrios Mougiakakos
Nov 14, 2012·Immunology and Cell Biology·Stephen P BurrOliver A Garden
Jan 8, 2013·American Journal of Respiratory and Critical Care Medicine·Jae W LeeMichael A Matthay
Oct 8, 2013·Cell Stem Cell·Maria Ester Bernardo, Willem E Fibbe
Dec 4, 2014·The Lancet. Respiratory Medicine·James WalterMichael A Matthay
Dec 21, 2014·Seminars in Immunopathology·Katharina L BeckerFrank L van de Veerdonk

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Citations

Aug 9, 2017·Journal of Cellular Biochemistry·Junfeng DuMin Li
May 1, 2020·Journal of Cellular Physiology·Seyed Mahdi Hosseiniyan KhatibiSepideh Zununi Vahed
Apr 11, 2020·Infection and Drug Resistance·Yongxuan HuLiyan Xi
Sep 14, 2021·Stem Cells and Development·Carolina Rodriguez-EcheverriAngel Gonzalez

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