Immunomodulatory effects of amniotic membrane matrix incorporated into collagen scaffolds

Journal of Biomedical Materials Research. Part a
Rebecca A HortensiusBrendan A C Harley

Abstract

Adult tendon wound repair is characterized by the formation of disorganized collagen matrix which leads to decreases in mechanical properties and scar formation. Studies have linked this scar formation to the inflammatory phase of wound healing. Instructive biomaterials designed for tendon regeneration are often designed to provide both structural and cellular support. In order to facilitate regeneration, success may be found by tempering the body's inflammatory response. This work combines collagen-glycosaminoglycan scaffolds, previously developed for tissue regeneration, with matrix materials (hyaluronic acid and amniotic membrane) that have been shown to promote healing and decreased scar formation in skin studies. The results presented show that scaffolds containing amniotic membrane matrix have significantly increased mechanical properties and that tendon cells within these scaffolds have increased metabolic activity even when the media is supplemented with the pro-inflammatory cytokine interleukin-1 beta. Collagen scaffolds containing hyaluronic acid or amniotic membrane also temper the expression of genes associated with the inflammatory response in normal tendon healing (TNF-α, COLI, MMP-3). These results suggest that a...Continue Reading

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Citations

Apr 25, 2018·Tissue Engineering. Part C, Methods·Hanis HasmadShiplu Roy Chowdhury
Dec 7, 2018·Expert Opinion on Biological Therapy·Jan AdamowiczTomasz Drewa
Apr 23, 2020·Journal of Biomedical Materials Research. Part a·Mathilde FenelonJean-Christophe Fricain
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Dec 16, 2020·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Sara Leal-MarinOleksandr Gryshkov
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Jun 4, 2021·Acta Biomaterialia·Jingyi HouHai-Quan Mao
Jul 13, 2021·Frontiers in Bioengineering and Biotechnology·Aleksandar JanevMateja Erdani Kreft
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Jan 30, 2019·ACS Biomaterials Science & Engineering·Rebecca A HortensiusBrendan A C Harley
Jan 16, 2021·ACS Biomaterials Science & Engineering·Leila SabouriMehdi Moghtadaei

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