Immunomodulatory effects of bone marrow-derived mesenchymal stem cells in a swine hemi-facial allotransplantation model.

PloS One
Yur-Ren KuoChao-Long Chen

Abstract

In this study, we investigated whether the infusion of bone marrow-derived mesenchymal stem cells (MSCs), combined with transient immunosuppressant treatment, could suppress allograft rejection and modulate T-cell regulation in a swine orthotopic hemi-facial composite tissue allotransplantation (CTA) model. Outbred miniature swine underwent hemi-facial allotransplantation (day 0). Group-I (n = 5) consisted of untreated control animals. Group-II (n = 3) animals received MSCs alone (given on days -1, +1, +3, +7, +14, and +21). Group-III (n = 3) animals received CsA (days 0 to +28). Group-IV (n = 5) animals received CsA (days 0 to +28) and MSCs (days -1, +1, +3, +7, +14, and +21). The transplanted face tissue was observed daily for signs of rejection. Biopsies of donor tissues and recipient blood sample were obtained at specified predetermined times (per 2 weeks post-transplant) or at the time of clinically evident rejection. Our results indicated that the MSC-CsA group had significantly prolonged allograft survival compared to the other groups (P<0.001). Histological examination of the MSC-CsA group displayed the lowest degree of rejection in alloskin and lymphoid gland tissues. TNF-α expression in circulating blood revealed sign...Continue Reading

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Citations

Nov 16, 2013·Current Opinion in Organ Transplantation·Nataša ObermajerMarc H Dahlke
Nov 22, 2013·Current Opinion in Organ Transplantation·Federica CasiraghiNorberto Perico
Oct 10, 2013·BioMed Research International·Angelo A Leto BaroneGerald Brandacher
Dec 21, 2012·Current Opinion in Organ Transplantation·Federica CasiraghiGiuseppe Remuzzi
Jun 27, 2014·Expert Review of Clinical Immunology·Lina CuiDaiming Fan
Nov 14, 2013·Current Opinion in Organ Transplantation·Christina L KaufmanJoseph E Kutz
Oct 12, 2013·Cytotherapy·Raquel CalloniJoão Antonio Pegas Henriques
Oct 24, 2015·Differentiation; Research in Biological Diversity·Young-Hoon KangBong-Wook Park
Jan 17, 2019·Tissue Engineering. Part a·Zhifang WuSonglin Wang
Nov 28, 2019·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Riccardo SchweizerJan A Plock
Oct 27, 2016·Plastic and Reconstructive Surgery·Ching-Ming ChienYur-Ren Kuo
Dec 17, 2014·Current Opinion in Cardiology·Philippe Menasché
May 7, 2020·Stem Cell Reviews and Reports·Alexander HalimGuanbin Song
Nov 5, 2015·Current Opinion in Organ Transplantation·Riccardo SchweizerJan A Plock
Jan 11, 2019·Annals of Plastic Surgery·Marco PappalardoAnna Barbara Di Stefano
Mar 8, 2019·Cellular & Molecular Immunology·Jasper IskeStefan G Tullius
Jul 3, 2020·International Journal of Molecular Sciences·Margarita EllosoMark G Jeschke

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Methods Mentioned

BETA
biopsy
biopsies
flow cytometry
ELISA
FACS
flow
enzyme-linked immunosorbent assay

Software Mentioned

Image
Pro Plus

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