Immunomodulatory effects of Caulerpa racemosa var peltata polysaccharide and its selenizing product on T lymphocytes and NK cells in mice

Science in China. Series C, Life Sciences
WeiZai ShenJingJing Tuo

Abstract

A polysaccharide, CrvpPS, was isolated from Caulerpa racemosa var peltata. It was reacted with nano-selenium in distilled water containing ascorbic acid (Vit C) to form a stable CrvpPS-nano-Se complex. The immunomodulatory effects of CrvpPS and CrvpPS-nano-Se on T lymphocytes subgroups and NK cells in mice were investigated. After intragastric administration for 10 days separately, both CrvpPS and CrvpPS-nano-Se showed significant stimulatory functions to thymus gland of mice. Moreover, the CrvpPS-nano-Se induced the percentage of CD3+, CD3+CD4+, NK cells and the CD4+/CD8+ value to increase significantly (P < 0.05) when analyzed by flow cytometry, which is better than the CrvpPS, sucrose-nano-Se, and even the positive drug levamisole.

References

Aug 30, 2000·Lancet·M P Rayman
Aug 2, 2003·Critical Reviews in Biotechnology·Honnavally P F Ramesh, Rudrapatnam N Tharanathan
Oct 30, 2003·Free Radical Biology & Medicine·Bo HuangChang Chen
Dec 29, 2004·Life Sciences·Jinsong ZhangLide Zhang

❮ Previous
Next ❯

Citations

Sep 6, 2011·Marine Drugs·Mariana Angelica Oliveira BitencourtJaneusa Trindade Souto
Jan 1, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Jiasheng ZhengCaixia Hu
Sep 1, 2012·International Journal of Biological Macromolecules·Junlong WangJi Zhang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.

© 2022 Meta ULC. All rights reserved