Immunomodulatory effects of damnacanthal isolated from roots of Morinda elliptica

Pharmaceutical Biology
Noorjahan Banu AlitheenA R Mashitoh

Abstract

Morinda elliptica Ridley (Rubiaceae) has been used traditionally as a medicine to treat various diseases in Malaysia and southeast Asia. In the present study we investigated the immunomodulatory effects of damnacanthal isolated from the roots of Morinda elliptica. The immunomodulatory effect of this compound was evaluated by using the lymphocyte proliferation assay with mouse thymocytes and human peripheral blood mononuclear cells (PBMC). In addition, the effect of the compound on PBMC cell cycle progression was studied by using flow cytometry. The production of human interleukin-2 and human inteleukin-12 cytokines was also assessed using the enzyme linked immunosorbent assay (ELISA) technique. The lymphocyte proliferation assay showed that damnacanthal was able to activate mouse thymocytes and PBMC at a low concentration (0.468 microg/mL). Moreover, the production of human interleukin-2 and human interleukin-12 cytokines in the culture supernatant from damnacanthal activated lymphocytes was markedly up-regulated at 24 h and sustained until 72 h with a slight decrease with time. A positive correlation was found between the level of these two cytokines and the MTT-based proliferation assay. Based on the above results, damnacanth...Continue Reading

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Citations

Feb 22, 2012·Phytotherapy Research : PTR·Amy C Brown
Oct 3, 2013·Asian Pacific Journal of Cancer Prevention : APJCP·Rakesh Kumar Gupta, Amit Kumar Patel
Oct 3, 2013·Asian Pacific Journal of Cancer Prevention : APJCP·Rakesh Kumar Gupta, Neeta Singh
Dec 17, 2019·Phytotherapy Research : PTR·Bharat Singh, Ram A Sharma
Aug 27, 2021·Environmental Toxicology·Sarwan W BradostyMahmood Ameen Abdulla

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