Immunomodulatory effects of dietary supplementation with a milk-based wolfberry formulation in healthy elderly: a randomized, double-blind, placebo-controlled trial

Rejuvenation Research
Karine VidalJalil Benyacoub

Abstract

Wolfberry (fruit of Lycium barbarum) has been prized for many years in China for its immunomodulatory property and its high specific antioxidant content. However, clear clinical evidence demonstrating the effect of wolfberry dietary supplementation is still lacking. After our earlier report showing that a proprietary milk-based wolfberry formulation (Lacto-Wolfberry) enhances in vivo antigen-specific adaptive immune responses in aged mice, the present study aimed at demonstrating the effect of dietary Lacto-Wolfberry supplementation on immune functions in the elderly, especially vaccine response known to decline with aging. A 3-month randomized, double-blinded, placebo-controlled study was conducted on 150 healthy community-dwelling Chinese elderly (65-70 years old) supplemented with Lacto-Wolfberry or placebo (13.7 grams/day). Immune response to influenza vaccine was assessed in the study, along with inflammatory and physical status. No serious adverse reactions were reported during the trial, neither symptoms of influenza-like infection. No changes in body weight and blood pressure, blood chemistry or cells composition, as well as autoantibodies levels were observed. The subjects receiving Lacto-Wolfberry had significantly hi...Continue Reading

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Citations

Oct 20, 2012·World Journal of Gastroenterology : WJG·David PhilippeKarine Vidal
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Jun 27, 2021·Pharmacology & Therapeutics·Zhiyong XiaoYongxiang Zhang

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Methods Mentioned

BETA
fluorescence-activated cell sorting
enzyme-linked immunosorbent assay
ELISA

Software Mentioned

CXP Analysis
GraphPad
LogXact
Plus
SPRIM
SAS

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