Immunomodulatory Effects of Kuseonwangdogo-Based Mixed Herbal Formula Extracts on a Cyclophosphamide-Induced Immunosuppression Mouse Model

Evidence-based Complementary and Alternative Medicine : ECAM
Joo Wan KimSae-Kwang Ku

Abstract

Kuseonwangdogo is a traditional Korean immunomodulatory polyherbal prescription. However, there are no systemic findings on its complex immunomodulatory effects on in vivo models. In this study, we observed the immunomodulatory effects of Kuseonwangdogo-based mixed herbal formula aqueous extracts (MHFe) on cyclophosphamide- (CPA-) induced immunosuppression mouse model. In total, 60 male 6-week-old ICR mice (10 mice/group) were selected based on body weight 24 h after the second CPA treatment and used in this experiment. Twelve hours after the end of the last (fourth) oral administration of MHFe, the animals were sacrificed. Following CPA treatment, a noticeable decrease in the body, thymus, spleen, and submandibular lymph node (LN) weights; white blood cell, red blood cell, platelet number, hemoglobin, and hematocrit concentrations; serum interferon-γ levels; splenic tumor necrosis factor-α, interleukin- (IL-) 1β, and IL-10 content; and peritoneal and splenic natural killer cell activities was observed. Depletion of lymphoid cells in the thymic cortex, splenic white pulp, and submandibular LN-related atrophic changes were also observed. However, these CPA-induced myelosuppressive signs were markedly and dose-dependently inhibit...Continue Reading

References

Apr 1, 1981·Clinical Otolaryngology and Allied Sciences·A Levene
Mar 1, 1982·Infection and Immunity·J L BenachJ A Cook
Aug 1, 1994·The Journal of Nutrition·R K Chandra, S Kumari
Mar 1, 1997·Clinical and Experimental Pharmacology & Physiology·J Ludbrook
Jan 1, 1997·Microbiology and Immunology·A EstradaB Laarveld
Feb 24, 2000·International Journal of Immunopharmacology·C G DuarteA I de Assis Pandochi
Aug 17, 2000·The Journal of Infectious Diseases·K L EricksonN E Hubbard
Jun 5, 2001·Bioscience, Biotechnology, and Biochemistry·J N LeeC W Kim
Jan 6, 2004·The Journal of Nutrition·Boon P Chew, Jean Soon Park
Mar 24, 2004·Journal of Ethnopharmacology·Eun Mi ChoiJae-Kwan Hwang
Feb 19, 2005·European Journal of Nutrition·Saleta SierraJordi Xaus
Apr 16, 2005·The Journal of Pharmacy and Pharmacology·Seyed Jalal Hosseinimehr, Mohmmad Karami
Jan 18, 2006·European Journal of Pharmacology·Chih-Peng LiuYuh-Chi Kuo
Jul 4, 2007·International Immunology·Wing Keung ChanGodfrey Chi-Fung Chan
Jun 1, 2011·Drug Design, Development and Therapy·Richard NicholasPaolo A Muraro
Jan 16, 2014·Journal of Food Science and Technology·Vellingiri MaheshuJagathala Mahalingam Sasikumar
Feb 7, 2014·Ayu·Divya KajariaBajrangi Lal Pandey
May 17, 2014·Frontiers in Pharmacology·Martha A ClarkCarla Cerami
Jul 17, 2014·Biological Research·Porkaew PromphetDuangkamol Kunthalert
Sep 23, 2014·International Journal of Biological Macromolecules·Chang-Won ChoHee-Do Hong
May 4, 2017·Cancer Prevention Research·Sourav BhattacharyaRatna B Ray
Sep 6, 2017·International Journal of Molecular Sciences·Khawaja Muhammad Imran Bashir, Jae-Suk Choi

❮ Previous
Next ❯

Methods Mentioned

BETA
ELISA

Software Mentioned

SPSS

Related Concepts

Related Feeds

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.