Immunomodulatory effects of platelets on the severity of hand, foot, and mouth disease infected with enterovirus 71.

Pediatric Research
Qianwen LiWei Guo

Abstract

Enterovirus 71 (EV71) infection contributes to hand, foot, and mouth disease (HFMD) with severe neurogenic complications, leading to higher morbidity. In addition to their typical roles in coagulation, platelets could serve as essential immune regulatory cells to play a key role in the pathogenesis of this viral infection. Platelet parameters were measured using an automatic hematology analyzer. T-helper type 1 (Th1) and Th2 cells were analyzed by flow cytometry. The levels of cytokines and key transcription factors were determined. The levels of platelet count and plateletcrit were positively associated with the severity of HFMD. Th1 and Th2 cells as well as their corresponding cytokines were increased in the severe group compared to the healthy volunteers. Moreover, the levels of platelets were negatively correlated with the level of interferon-γ (IFN-γ), but positively correlated with the frequency of Th1 cells. Coculture of platelets and naive CD4+ T cells showed that platelets from mild patients promote Th1 cell differentiation and IFN-γ secretion. Our study has shown for the first time that the distinct roles of platelets are responsible for the regulation of pathogenic CD4+ T cell differentiation and function in the path...Continue Reading

References

Jul 29, 2006·Journal of Virology·Fiona J CulleyPeter J M Openshaw
Jun 10, 2011·Thrombosis and Haemostasis·Norbert GerdesNailin Li
Aug 22, 2015·Thrombosis and Haemostasis·Mark R Thomas, Robert F Storey
Aug 22, 2015·Circulation Research·Sarah S StarossomEugene D Ponomarev
Nov 3, 2016·Seminars in Immunology·Matteo Iannacone
Feb 1, 2017·Scientific Reports·Amrita OjhaPrasenjit Guchhait
May 26, 2017·Frontiers in Cellular and Infection Microbiology·Ting ZhaoQihan Li
May 31, 2017·Nature Communications·Yunmei WangDaniel I Simon
Sep 29, 2017·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Rachel S MorrisMartin G Schwacha
Nov 23, 2017·Seminars in Thrombosis and Hemostasis·Seok-Joo KimCraig N Jenne
May 17, 2018·Laboratory Investigation; a Journal of Technical Methods and Pathology·Yuefei JinGuangcai Duan
Aug 25, 2018·Science·Margarita Pons-Salort, Nicholas C Grassly
Oct 4, 2018·World Journal of Pediatrics : WJP·Xing-Wang LiTao Yang
Nov 30, 2018·Frontiers in Medicine·Felix EisingerHarald F Langer
Nov 30, 2018·Annual Review of Immunology·Craig N MorrellDenisse Vega Ocasio
Jan 5, 2019·Journal of Cellular and Molecular Medicine·Yajing ZhaoMing Hou

❮ Previous
Next ❯

Software Mentioned

FlowJo
GraphPad Prism
GraphPad

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.