Immunomodulatory effects of rexinoids

Seminars in Oncology
Francine Foss

Abstract

Rexinoids have shown clinical activity in hematologic malignancies by mediating genes associated with both growth and differentiation. Consequently, these compounds are increasingly being investigated for the treatment of cutaneous T-cell lymphomas. Combining rexinoids with interleukin-2 receptor-targeted therapies, such as denileukin diftitox, would appear to be a rational therapy option in the treatment of lymphoid malignancies. This article discusses the use of rexinoids in combination with these pharmacotherapeutic agents, together with their use in combination with extracorporeal photophoresis and explores practical clinical approaches that may help to evoke immunomodulatory effects in targeted tumor cells, and ultimately lead to improved clinical outcome.

References

Feb 5, 1987·The New England Journal of Medicine·R EdelsonG Plewig
Dec 1, 1996·Journal of the American Academy of Dermatology·J A ZicL E King
Jul 23, 1998·Journal of the American Academy of Dermatology·M N SalehJ C Nichols
Nov 20, 2003·Clinical Lung Cancer·Heather DeGrendele
Apr 2, 2004·Expert Review of Anticancer Therapy·Len T Farol, Kenneth B Hymes
Dec 30, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Wan-Ching YenWilliam W Lamph
Jan 6, 2005·The Oncologist·James R Rigas, Konstantin H Dragnev

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Citations

Dec 2, 2009·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Calogero D'AlessandriaAlberto Signore
Oct 22, 2013·La Revue de médecine interne·R GoulabchandP Guilpain
Jun 10, 2008·Expert Opinion on Emerging Drugs·Dominik Sebastian MestelWolfram Sterry
Mar 28, 2007·Cancer Control : Journal of the Moffitt Cancer Center·Dorna RezaniaHernani D Cualing

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