Immunomodulatory effects of silymarin after subacute exposure to mice: A tiered approach immunotoxicity screening

Journal of Pharmacopuncture
Gholamreza KarimiBamdad Riahi-Zanjani

Abstract

Silymarin is a flavonoid complex extracted from the Silybum marianum plant with a wide range of pharmacological and biochemical effects. In the present study, the immunomodulatory effects of silymarin were investigated in BALB/c mice. Silymarin was administered daily by intraperitoneal injection at doses of 50, 100 and 150 mg/kg for 14 consecutive days. Following the exposure, host hematological parameters, spleen cellularity and histopathological examination, as well as delayed-type hypersensitivity (DTH) responses, hemagglutination titers (HA), splenocyte cytokine production and lymphocyte proliferation assay were studied in all of the test groups of animals. The results showed that the low dose of silymarin (50 mg/kg) could stimulate both cellular and humoral immune functions in the treated hosts. In addition, silymarin at 100 mg/kg appeared to impact on DTH responses and lymphoproliferation. Based on the finding here, it would seem that silymarin has efficient immunostimulant properties. As a recommendation, the application of silymarin along with acupuncture technique (herbal acupuncture) can be thought as a good plan to modulate and enhance the immune system for the management of several immunodeficiency disorders. Howeve...Continue Reading

References

Apr 5, 2003·Environmental Health Perspectives·Michael I LusterDori R Germolec
Mar 24, 2004·Toxicology·E Zabihi NeishabouriS N Ostad
Mar 24, 2004·International Immunopharmacology·Victor M VictorMonica De la Fuente
Jan 28, 2006·Redox Report : Communications in Free Radical Research·Helen R Griffiths
Jan 1, 1993·Mediators of Inflammation·V Witko-SarsatB Descamps-Latscha
Jun 28, 2008·Cell Cycle·Stefan M SchiekeToren Finkel
Mar 12, 2009·Inflammation & Allergy Drug Targets·Shirin Hasani-RanjbarMohammad Abdollahi
Jan 9, 2010·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Marjan GharagozlooCarlo Riccardi
Mar 30, 2010·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·B RiahiG Karimi
Sep 29, 2011·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Mehdi BakhshaeeMohammad Ali Zamani
Jul 31, 2012·Biochemical and Biophysical Research Communications·Yun Ho ChoiGuang Hai Yan
Mar 29, 2014·World Journal of Hepatology·Nancy Vargas-MendozaJosé A Morales-González
Jul 17, 2014·Journal of Immunotoxicology·Maryam RahnamaBamdad Riahi-Zanjani
Jun 1, 2015·Environmental Toxicology and Pharmacology·Kobra ShiraniGholamreza Karimi
Jun 24, 2015·Journal of Immunotoxicology·Mahmoud MahmoudiBamdad Riahi-Zanjani
Mar 22, 2016·Advances in Pharmacological Sciences·Hadi Darvishi KhezriArash Hadian Amree
Mar 30, 2016·Drug Design, Development and Therapy·Fatma M MadyAmal K Hussein

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Citations

Jun 27, 2020·Frontiers in Pharmacology·Elisa CeccheriniSilvia Rocchiccioli

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