Immunomodulatory effects of Streptococcus suis capsule type on human dendritic cell responses, phagocytosis and intracellular survival.

PloS One
Marjolein MeijerinkJerry M Wells

Abstract

Streptococcus suis is a major porcine pathogen of significant commercial importance worldwide and an emerging zoonotic pathogen of humans. Given the important sentinel role of mucosal dendritic cells and their importance in induction of T cell responses we investigated the effect of different S. suis serotype strains and an isogenic capsule mutant of serotype 2 on the maturation, activation and expression of IL-10, IL-12p70 and TNF-α in human monocyte-derived dendritic cells. Additionally, we compared phagocytosis levels and bacterial survival after internalization. The capsule of serotype 2, the most common serotype associated with infection in humans and pigs, was highly anti-phagocytic and modulated the IL-10/IL-12 and IL-10/TNF-α cytokine production in favor of a more anti-inflammatory profile compared to other serotypes. This may have consequences for the induction of effective immunity to S. suis serotype 2 in humans. A shielding effect of the capsule on innate Toll-like receptor signaling was also demonstrated. Furthermore, we showed that 24 h after phagocytosis, significant numbers of viable intracellular S. suis were still present intracellularly. This may contribute to the dissemination of S. suis in the body.

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Citations

Feb 24, 2016·Gut Microbes·Maria Laura Ferrando, Constance Schultsz
Dec 20, 2014·The Journal of Infectious Diseases·Maria Laura FerrandoConstance Schultsz
Sep 18, 2012·PloS One·Marie-Pier LecoursMarcelo Gottschalk
Dec 3, 2016·Scientific Reports·Marie-Pier LecoursMariela Segura
Mar 22, 2016·PloS One·Edoardo ZaccariaPeter van Baarlen
Oct 27, 2018·Frontiers in Microbiology·Nuria Castro-BravoPatricia Ruas-Madiedo
Jan 20, 2021·Physiological Reports·Melinda A EngevikJames Versalovic

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Methods Mentioned

BETA
flow cytometry
Fluorescence
transmission electron microscopy

Software Mentioned

BD FACSDiva
BD FCAP

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