Immunomodulatory effects of Treg and Th17 cells in parasitic infections and hygiene hypothesis

Zhongguo xue xi chong bing fang zhi za zhi = Chinese journal of schistosomiasis control
Yang Ying-Ying, Yang Jun-Qi

Abstract

The parasitic infection is still a severe public health problem in developing countries, which threatens people's health and social development. With the advances of molecular biology and immunology, more and more insights have been reached on the immunity and immunopathogenesis to parasitic infections. CD4+ T cells play a central role in the host's immunosurveillance and immunoregulation. Traditionally, naive CD4+ T cells are considered to be able to differentiate into Th1 and Th2 cell subsets both in vivo and in vitro. These Th1 and Th2 cells secret diverse cytokine profiles to exert different functions. Later, two new subsets of CD4+ T cells, Th17 and Treg cells, have been discovered. They are completely different from traditional Th1 and Th2 cells with independent differentiation and regulation mechanism. Ample studies suggest that Treg and Th17 cells play a key role in a variety of parasitic diseases. Furthermore, Treg and Th17 cells have been got increasing attention for their involvement in the hygiene hypothesis. Based on the current advances of researches of Treg and Th17 cells, we make a brief review about immunomodulatory effects of these two subsets in parasitic infections as well as the hygiene hypothesis.

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Related Papers

Journal of Biomedicine & Biotechnology
Luis I TerrazasJorge Morales-Montor
Zhongguo xue xi chong bing fang zhi za zhi = Chinese journal of schistosomiasis control
Xiao-lin FanJun-qi Yang
Annual Review of Immunology
Jinfang ZhuWilliam E Paul
Advances in Experimental Medicine and Biology
Bing Sun, Yuan Zhang
© 2022 Meta ULC. All rights reserved