Immunomodulatory Function of Myeloid-Derived Suppressor Cells during B Cell-Mediated Immune Responses

International Journal of Molecular Sciences
Bilgenaz ÖzkanSung Gyoo Park

Abstract

Myeloid-derived suppressor cells (MDSCs) play roles in immune regulation during neoplastic and non-neoplastic inflammatory responses. This immune regulatory function is directed mainly toward T cells. However, MDSCs also regulate other cell populations, including B cells, during inflammatory responses. Indeed, B cells are essential for antibody-mediated immune responses. MDSCs regulate B cell immune responses directly via expression of effector molecules and indirectly by controlling other immune regulatory cells. B cell-mediated immune responses are a major component of the overall immune response; thus, MDSCs play a prominent role in their regulation. Here, we review the current knowledge about MDSC-mediated regulation of B cell responses.

References

Apr 1, 1992·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·G S Kansas
Oct 1, 1991·Immunology Today·R P PhippsR L Roper
Apr 24, 1999·Science·J B MannickJ S Stamler
Feb 20, 2003·The Journal of Experimental Medicine·Claudia MauriMarco Londei
Jul 30, 2003·Journal of Leukocyte Biology·Sergei Kusmartsev, Dmitry I Gabrilovich
Jan 7, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sergei KusmartsevDmitry I Gabrilovich
Aug 2, 2005·Nature Reviews. Immunology·Vincenzo Bronte, Paola Zanovello
Sep 24, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hyung W LimChang H Kim
Sep 28, 2005·The Journal of Experimental Medicine·Paulo C RodriguezAugusto C Ochoa
Jan 19, 2006·Blood·Dong-Mei ZhaoEthan M Shevach
Feb 14, 2006·The American Journal of Clinical Nutrition·Andrew S Greenberg, Martin S Obin
Jan 27, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Augusto C OchoaPaulo C Rodriguez
Feb 22, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kim H T ParaisoWilliam G Kerr
May 8, 2007·Cancer Research·Pratima SinhaSuzanne Ostrand-Rosenberg
Jun 6, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jamie G EvansClaudia Mauri
Jul 3, 2007·Nature Medicine·Srinivas NagarajDmitry I Gabrilovich
Aug 19, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ingo FrickeDmitry I Gabrilovich
Aug 24, 2007·Proceedings of the National Academy of Sciences of the United States of America·M GrayJ Savill
Oct 4, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Je-In YounDmitry I Gabrilovich
Feb 7, 2009·Nature Reviews. Immunology·Dmitry I Gabrilovich, Srinivas Nagaraj
Mar 6, 2009·Journal of Leukocyte Biology·Stephanie K BuntSuzanne Ostrand-Rosenberg
Apr 4, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Suzanne Ostrand-Rosenberg, Pratima Sinha
Jun 26, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Erica M HansonSuzanne Ostrand-Rosenberg
Jul 3, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Noriko IikuniAntonio La Cava
Dec 24, 2009·Cancer Research·Minu K SrivastavaSuzanne Ostrand-Rosenberg
Jun 17, 2010·The Journal of Clinical Investigation·Mercedes Rodriguez GarciaJordi C Ochando
Oct 19, 2010·Molecular Immunology·Gaetano VitaleCarlo Pucillo
Jan 10, 2012·Annual Review of Immunology·Claudia Mauri, Anneleen Bosma
Jun 22, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Tangying Lu, Dmitry I Gabrilovich
Jul 27, 2012·Cell Reports·Yun-Hee YoumVishwa Deep Dixit
Sep 25, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Fareena A Bilwani, Katherine L Knight
Oct 16, 2012·The Journal of Clinical Investigation·Xueqiang ZhaoZhihai Qin
Feb 2, 2013·Transplantation Research·Nataša Obermajer, Pawel Kalinski
Jun 12, 2013·Cancer Microenvironment : Official Journal of the International Cancer Microenvironment Society·Galina V ShurinMichael R Shurin
Aug 21, 2013·Immunological Reviews·Celeste GohYoung S Hahn

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Citations

Jun 30, 2019·Cancers·Prachi GuptaSunila Pradeep
Sep 27, 2019·European Journal of Immunology·Jennifer JaufmannSandra Beer-Hammer
Jan 25, 2020·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Ruiting WenZhigang Yang
May 18, 2020·American Journal of Reproductive Immunology : AJRI·Zi-Meng ZhengJun Shao
Aug 15, 2018·International Journal of Molecular Sciences·Tsukasa Nakamura, Hidetaka Ushigome
Sep 18, 2020·Cancers·Michał ZarobkiewiczAgnieszka Bojarska-Junak
May 30, 2019·Frontiers in Immunology·Monica VaccariGenoveffa Franchini
Feb 23, 2019·Cellular and Molecular Life Sciences : CMLS·Antero SalminenAnu Kauppinen
Apr 5, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Bernardo L RapoportRonald Anderson
Jan 23, 2021·Life Sciences·Jamshid Gholizadeh NavashenaqAmirhossein Sahebkar
Jun 3, 2021·International Journal of Molecular Sciences·Arshi KhanamShyam Kottilil
Aug 26, 2021·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Antero Salminen

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