Immunomodulatory placental-expanded, mesenchymal stromal cells improve muscle function following hip arthroplasty

Journal of Cachexia, Sarcopenia and Muscle
T WinklerHans-Dieter Volk

Abstract

No regenerative approach has thus far been shown to be effective in skeletal muscle injuries, despite their high frequency and associated functional deficits. We sought to address surgical trauma-related muscle injuries using local intraoperative application of allogeneic placenta-derived, mesenchymal-like adherent cells (PLX-PAD), using hip arthroplasty as a standardized injury model, because of the high regenerative and immunomodulatory potency of this cell type. Our pilot phase I/IIa study was prospective, randomized, double blind, and placebo-controlled. Twenty patients undergoing hip arthroplasty via a direct lateral approach received an injection of 3.0 × 108 (300 M, n = 6) or 1.5 × 108 (150 M, n = 7) PLX-PAD or a placebo (n = 7) into the injured gluteus medius muscles. We did not observe any relevant PLX-PAD-related adverse events at the 2-year follow-up. Improved gluteus medius strength was noted as early as Week 6 in the treatment-groups. Surprisingly, until Week 26, the low-dose group outperformed the high-dose group and reached significantly improved strength compared with placebo [150 M vs. placebo: P = 0.007 (baseline adjusted; 95% confidence interval 7.6, 43.9); preoperative baseline values mean ± SE: placebo: 24....Continue Reading

References

Aug 6, 2000·British Journal of Anaesthesia·J P Desborough
Jul 19, 2001·Proceedings of the National Academy of Sciences of the United States of America·S J Lee, A C McPherron
Jul 20, 2005·Current Drug Targets·Katsuya Kami, Emiko Senba
Sep 6, 2005·Science·Didier MontarrasMargaret Buckingham
Oct 21, 2006·Clinical Orthopaedics and Related Research·Leo A WhitesideBrian J Katerberg
May 21, 2008·The International Journal of Biochemistry & Cell Biology·Kitipong UaesoontrachoonCharles N Pagel
Nov 14, 2008·Stem Cells and Development·Sarah BarlowKerry Atkinson
Jul 5, 2012·Journal of Tissue Engineering and Regenerative Medicine·Tobias WinklerCarsten Perka
Oct 2, 2012·The Journal of Clinical Investigation·Peng HongM A Q Siddiqui
Jul 9, 2013·The Journal of Surgical Research·Rajika RoyChristof Stamm
Feb 11, 2014·Exercise and Sport Sciences Reviews·Jonathan P Farthing, E Paul Zehr
Jun 7, 2014·Clinical Journal of Sport Medicine : Official Journal of the Canadian Academy of Sport Medicine·Dai SugimotoTimothy E Hewett
Jul 6, 2014·Cell Stem Cell·Arin B Aurora, Eric N Olson
Apr 12, 2015·FEBS Letters·Yoshihiro NakamuraMitsuo Ochi
May 26, 2015·Journal of Electromyography and Kinesiology : Official Journal of the International Society of Electrophysiological Kinesiology·Jessica A MutchlerBonnie L Van Lunen
Jun 9, 2015·The Journal of Clinical Investigation·Chang H LeeJeremy J Mao
Apr 5, 2016·Ageing Research Reviews·Jasdeep SainiNasser Al-Shanti
Nov 4, 2017·Journal of Cachexia, Sarcopenia and Muscle·Stephan von HaehlingStefan D Anker

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Citations

Nov 6, 2018·Clinical Pharmacology and Therapeutics·Ram R Miller, Ronenn Roubenoff
Mar 8, 2019·Journal of Cachexia, Sarcopenia and Muscle·Taimoor H QaziTobias Winkler
May 24, 2019·Circulation Research·Carsten TschöpeSophie Van Linthout
Dec 6, 2019·Stem Cells Translational Medicine·Maciej KabatMartin Grumet
Jul 18, 2020·Journal of Cachexia, Sarcopenia and Muscle·Tobias Winkler, Georg N Duda
Sep 29, 2020·Seminars in Musculoskeletal Radiology·Ian Beggs
Apr 27, 2019·Frontiers in Bioengineering and Biotechnology·Antonietta R SiliniOrnella Parolini
Feb 13, 2020·Journal of Cachexia, Sarcopenia and Muscle·Nicole EbnerStephan von Haehling
Sep 29, 2020·Critical Care Explorations·Ravit BarkamaAyelet Raz Pasteur
Jul 6, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Maurizio MuracaEugenio Baraldi
Apr 4, 2021·International Journal of Molecular Sciences·Natalia ZiemkiewiczKoyal Garg
May 6, 2021·Journal of Personalized Medicine·Wanda LattanziOrnella Parolini
Jun 8, 2021·Frontiers in Bioengineering and Biotechnology·Martina SandonàValentina Saccone
Oct 14, 2019·ACS Biomaterials Science & Engineering·Taimoor H QaziSven Geissler
Jan 6, 2022·Journal of Cachexia, Sarcopenia and Muscle·Tazio MaleitzkeTobias Winkler

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Methods Mentioned

BETA
total hip arthroplasty
biopsy
dissection
force measurements
biopsies
ELISA
the

Clinical Trials Mentioned

NCT01525667

Software Mentioned

Osirix
SAS
Axiovision
Image Software Photoshop
Pluristem
ImageJ

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