Immunomodulatory potential of Rhein, an anthraquinone moiety of Cassia occidentalis seeds

Toxicology Letters
Gati Krushna PanigrahiMukul Das

Abstract

Rhein, the most toxic anthraquinone moiety in Cassia occidentalis seeds, has been associated with hepatomyoencephalopathy (HME) in children. Structural and functional alterations in the lymphoid organs have been reported both in HME patients and experimental animals indicating a possibility of the dysfunction of immune system following exposure to CO seeds or its toxic anthraquinones (Panigrahi et al., 2014a). In the present study the mechanism of immune response of Rhein in splenocytes has been investigated by measuring functional assays of lymphocyte, cell surface receptor expression and analysis of cytokine levels. Results indicate that Rhein at a maximum dose of 10 μM is non cytotoxic up to 72 h in splenocytes. In addition to its potential to decrease the allogenic response of T-cells, Rhein significantly suppresses the proliferation of the concavalin A (Con A) and lipopolysaccharide (LPS) stimulated splenocytes. Lymphocyte receptor expression analysis revealed that Rhein exposure significantly down regulate the expression of CD3e, CD4, CD8, CD28, CD69 molecules in T-cells. The expression of CD19, CD28, CD40 in B-cells were also found to be significantly decreased following Rhein exposure. In accordance with the functional ...Continue Reading

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Citations

Aug 11, 2020·Natural Products and Bioprospecting·Pukar KhanalYasmin Naaz
Nov 27, 2020·Molecular Biology Reports·Biswajita PradhanMrutyunjay Jena
Feb 16, 2021·Molecular and Cellular Biochemistry·Bhoomika PatelMahaveer Dhobi

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